Ca2+ release-activated channels in rat stomach smooth muscle cells

European Journal of Pharmacology
S S SmailiA Jurkiewicz

Abstract

In rat stomach fundus, contractions induced by Ca2+ (1.8 mM) were strikingly potentiated by thapsigargin. This potentiation was partially inhibited by the blockers of Ca2+ release activated channels (CRACs), miconazole and SK&F96365 ([1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCL]) and slightly blocked by the antagonist of calcium voltage-operated channels (VOCs), isradipine. In dissociated cells in a 0Ca solution, thapsigargin potentiated the increase in intracellular calcium after reintroduction of Ca2+. This potentiation was partially reduced by the CRAC blockers, but not by the VOC blockers. This data suggests that calcium influx increased due to the depletion of intracellular calcium by thapsigargin and that this influx occurs predominantly through CRACs.

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Citations

Jun 6, 2003·European Journal of Pharmacology·Rosana de A RibeiroAron Jurkiewicz
Jun 16, 2001·British Journal of Pharmacology·S IeiriH Kanaide
Mar 29, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Guiomar Silva LopesNeide Hyppolito Jurkiewicz
Feb 16, 2002·The Japanese Journal of Physiology·S YonedaM Takaki
Jun 3, 2014·Cell Calcium·Gustavo J S PereiraSoraya S Smaili
Dec 14, 2005·Experimental Gerontology·Guiomar S LopesSoraya S Smaili
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Aron JurkiewiczNeide H Jurkiewicz
Oct 23, 2004·Cell Death and Differentiation·A C P CarvalhoS S Smaili
Dec 13, 2000·The Journal of Biological Chemistry·E S TrepakovaV M Bolotina
Dec 21, 2018·Anais Da Academia Brasileira De Ciências·Paulo M S CavalcantiSuzana M G Cavalcanti
Oct 9, 2008·European Journal of Pharmacology·Adriana Gonzalez ValeraNeide Hyppolito Jurkiewicz

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