PMID: 8956502Jan 1, 1996Paper

Ca2+ sensitivity and caffeine-induced changes in skinned cardiac muscle fibers of the carp, Cyprinus carpio

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
A ChugunN Kurebayashi

Abstract

Ca2+ sensitivity and caffeine-induced sensitivity changes in skinned carp heart fibers were compared with those of guinea pig and rat heart. The Ca2+ concentration-response curves of saponin-treated left atrial skinned fibers obtained from guinea pig and rat were almost identical. Doses of 5 and 20 mmol.l-1 caffeine shifted this curve to the left. However, when a relatively high concentration (50 mmol.l-1) of caffeine was used, the left-ward shift was reduced. Caffeine reduced the peak of the Ca2+ concentration-response curve. The Ca2+ concentration-response curve of carp atrial skinned fiber is almost identical to that of guinea pig and rat. However, a further increase in Ca2+ sensitivity was observed even when 50 mmol.l-1 caffeine was added. Similarly, a decrease in the response curve peak was also observed. Ca2+ sensitivity in ventricular skinned fibers obtained from carp was almost the same as that observed for the atrial, but the increase in Ca2+ sensitivity due to caffeine was larger. In addition, a further increase was also observed when 50 mmol.l-1 caffeine was added. These results indicate that the Ca2+ sensitivity of contractile proteins in atrial muscles from carp heart is the same as that of guinea pig and rat. It i...Continue Reading

References

Jul 1, 1992·Pflügers Archiv : European journal of physiology·D S Steele, G L Smith
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·R M Santer, J L Cobb
Apr 1, 1982·Canadian Journal of Physiology and Pharmacology·J P Morgan, J R Blinks
Aug 1, 1983·Pflügers Archiv : European journal of physiology·I R Wendt, D G Stephenson

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Citations

Jul 30, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A ChugunH Kondo

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