Ca(2+) sensor proteins in dendritic spines: a race for Ca(2+).

Frontiers in Molecular Neuroscience
Vijeta RaghuramMichael R Kreutz

Abstract

Dendritic spines are believed to be micro-compartments of Ca(2+) regulation. In a recent study, it was suggested that the ubiquitous and evolutionarily conserved Ca(2+) sensor, calmodulin (CaM), is the first to intercept Ca(2+) entering the spine and might be responsible for the fast decay of Ca(2+) transients in spines. Neuronal calcium sensor (NCS) and neuronal calcium-binding protein (nCaBP) families consist of Ca(2+) sensors with largely unknown synaptic functions despite an increasing number of interaction partners. Particularly how these sensors operate in spines in the presence of CaM has not been discussed in detail before. The limited Ca(2+) resources and the existence of common targets create a highly competitive environment where Ca(2+) sensors compete with each other for Ca(2+) and target binding. In this review, we take a simple numerical approach to put forth possible scenarios and their impact on signaling via Ca(2+) sensors of the NCS and nCaBP families. We also discuss the ways in which spine geometry and properties of ion channels, their kinetics and distribution, alter the spatio-temporal aspects of Ca(2+) transients in dendritic spines, whose interplay with Ca(2+) sensors in turn influences the race for Ca(2+).

Citations

Jul 25, 2014·PloS One·Pasham Parameshwar ReddyMichael R Kreutz
Dec 3, 2014·Biochimica Et Biophysica Acta·Robert D Burgoyne, Lee P Haynes
Feb 24, 2015·Protein Expression and Purification·Anand Kumar SharmaVangipurapu Rajanikanth
Mar 12, 2015·Frontiers in Cellular Neuroscience·Stefano MasoliEgidio D'Angelo
Dec 19, 2014·Frontiers in Neuroanatomy·Roberto Araya
Aug 27, 2015·Molecular & Cellular Proteomics : MCP·Daniela C Dieterich, Michael R Kreutz
Jul 30, 2019·Frontiers in Synaptic Neuroscience·Diana E MitchellRoberto Araya
Feb 23, 2019·Frontiers in Molecular Neuroscience·Jennifer MundhenkMichael R Kreutz
Jun 11, 2014·Biochimica Et Biophysica Acta·Saman Ebrahimi, Shigeo Okabe
Mar 28, 2021·Biophysical Journal·Yinbo Chen, Victor Matveev
Jul 18, 2021·Biochemical and Biophysical Research Communications·Regur PhanindranathYogendra Sharma
Feb 23, 2020·Journal of the American Chemical Society·Haichao WuDaniel K Schwartz
Apr 25, 2017·Biochemistry·Uday KiranAsima Chakraborty

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Methods Mentioned

BETA
VILIPs
myristoylation
super-resolution microscopy

Software Mentioned

DREAM
Cytoscape

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