Ca2+ signaling and Src-kinases-controlled cellular functions

Archives of Biochemistry and Biophysics
Estefanía Anguita, Antonio Villalobo

Abstract

Calcium-mediated signaling and the functionality of Src-family tyrosine kinases (SFKs) are two interconnected processes. Activation of these kinases, which are coupled to a series of receptors, mediates Ca2+ mobilization by regulating Ca2+ channels, and the generated Ca2+ signal in turn exerts control on the kinase activity via calmodulin. In this review, we shall cover the regulation of selected processes where crosstalk between the functionality of SFKs and the Ca2+ signal occurs during the lifespan of the cell, when subjected to different extracellular or intracellular stimuli. These events result in the modulation of many physiological processes, which are essential to maintain organismal homeostasis. We discuss the importance of these mechanisms, and the implicated signaling pathways on essential cellular processes, comprising proliferation, differentiation, cell adhesion, migration, cytoskeletal remodeling, oocyte fertilization, apoptosis and autophagy. Thereafter, we discuss the role that Ca2+ and SFKs exert in the control of selected physiological functions, including hormones/neurotransmitters release, striated and smooth muscle contraction, glomerular filtration, stress response, and the cellular response to viral and...Continue Reading

Citations

Jan 30, 2020·International Journal of Molecular Sciences·Simona MartinottiElia Ranzato
Mar 17, 2020·Cancer Biology & Therapy·Nefeli ZacharopoulouChristos Stournaras
Jan 30, 2019·Nature Reviews. Nephrology·Patrick Ming-Kuen TangHui-Yao Lan
Nov 27, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aziz Ur Rehman AzizBo Liu
Dec 24, 2018·The Biochemical Journal·Antonio Villalobo
Jan 30, 2020·International Journal of Molecular Sciences·Antonio Villalobo, Martin W Berchtold
Feb 12, 2021·Biophysics Reviews·Stephen J P PrattStuart S Martin
Feb 27, 2021·The Biochemical Journal·Giuliano Molinari, Elsa Nervo
Jun 10, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennifer K TrittmannLeif D Nelin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Related Papers

Biochimica Et Biophysica Acta. Molecular Cell Research
Estefanía Anguita, Antonio Villalobo
Current Genomics
E Lucas-FernándezAntonio Villalobo
© 2022 Meta ULC. All rights reserved