Ca(2+) signaling in the myocardium by (redox) regulation of PKA/CaMKII

Frontiers in Pharmacology
Alex S JohnstonJoseph R Burgoyne

Abstract

Homeostatic cardiac function is maintained by a complex network of interdependent signaling pathways which become compromised during disease progression. Excitation-contraction-coupling, the translation of an electrical signal to a contractile response is critically dependent on a tightly controlled sequence of events culminating in a rise in intracellular Ca(2+) and subsequent contraction of the myocardium. Dysregulation of this Ca(2+) handling system as well as increases in the production of reactive oxygen species (ROS) are two major contributing factors to myocardial disease progression. ROS, generated by cellular oxidases and by-products of cellular metabolism, are highly reactive oxygen derivatives that function as key secondary messengers within the heart and contribute to normal homeostatic function. However, excessive production of ROS, as in disease, can directly interact with kinases critical for Ca(2+) regulation. This post-translational oxidative modification therefore links changes in the redox status of the myocardium to phospho-regulated pathways essential for its function. This review aims to describe the oxidative regulation of the Ca(2+)/calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinas...Continue Reading

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Citations

Dec 2, 2015·Biochimica Et Biophysica Acta·Sören BrandenburgStephan E Lehnart
Jun 16, 2018·Basic Research in Cardiology·Jan BeckendorfJohannes Backs
Aug 16, 2019·European Journal of Preventive Cardiology·Alberto AimoAlberto Giannoni
Dec 24, 2018·Frontiers in Physiology·Roman NikolaienkoAleksey V Zima
Feb 2, 2021·Circulation·Kirsten T NijholtB Daan Westenbrink
Mar 16, 2021·Free Radical Biology & Medicine·Diana Bou-TeenMarisol Ruiz-Meana
Apr 25, 2021·The Journal of Biological Chemistry·Paraskevi KritsiligkouChris M Grant
May 22, 2021·Free Radical Biology & Medicine·David Weissman, Christoph Maack

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Methods Mentioned

BETA
affinity purification
electrophoresis

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