Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans

Neuron
M GomezP Nef

Abstract

On a radial temperature gradient, C. elegans worms migrate, after conditioning with food, toward their cultivation temperature and move along this isotherm. This experience-dependent behavior is called isothermal tracking (IT). Here we show that the neuron-specific calcium sensor-1 (NCS-1) is essential for optimal IT. ncs-1 knockout animals show major defects in IT behavior, although their chemotactic, locomotor, and thermal avoidance behaviors are normal. The knockout phenotype can be rescued by reintroducing wild-type NCS-1 into the AIY interneuron, a key component of the thermotaxis network. A loss-of-function form of NCS-1 incapable of binding calcium does not restore IT, whereas NCS-1 overexpression enhances IT performance levels, accelerates learning (faster acquisition), and produces a memory with slower extinction. Thus, proper calcium signaling via NCS-1 defines a novel pathway essential for associative learning and memory.

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Citations

Dec 18, 2002·Journal of Neurobiology·Fred W Wolf, Ulrike Heberlein
Dec 18, 2002·Journal of Neurobiology·Oliver Hobert
Jan 2, 2010·Archives of Environmental Contamination and Toxicology·Yanfen ZhangDayong Wang
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Feb 15, 2008·Neuroscience Bulletin·Hua-Yue YeDa-Yong Wang
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