Ca2+ signalling of kinins in cells expressing rat, mouse and human B1/B2-receptor

International Immunopharmacology
Radka ZubakovaUlrich Hilgenfeldt

Abstract

With respect to functional aspects, the kallikrein-kinin-system can be divided into a plasma kallikrein-kinin-system and a tissue kallikrein-kinin-system. At least four functional kinin peptides act via two different G-protein-coupled receptors, an inducible B1-receptor and a constitutively expressed B2-receptor. B1R and B2R couple to G(q/11) and lead via phospholipase C to Ca2+ mobilization. In humans both, bradykinin and kallidin are agonists on the B2-receptor. In contrast, bradykinin is believed to be the only kinin acting on the B2R in rats and mice. However, recently we have isolated a kallidin-like-peptide from plasma and urine of rats. Until now the kinin ligand-receptor interactions were mainly characterized in binding studies. However, receptor affinity does not inevitably correspond with the intrinsic activity of an agonist. The aim of the present study was to investigate intracellular calcium mobilization to quantify mouse, rat and human B1- and B2-receptor activation by bradykinin, kallidin, des-Arg9-bradykinin, des-Arg10-kallidin, and of the two novel rat kinins, kallidin-like-peptide and des-Arg10-kallidin-like-peptide. In cells stably expressing the human, rat, and mouse B2-receptor, respectively, bradykinin, ka...Continue Reading

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Citations

Apr 24, 2014·Pflügers Archiv : European journal of physiology·Marina DobrivojevićAleksandra Sinđić
Aug 6, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Isis C NascimentoHenning Ulrich
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Feb 23, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yaping ZhangCang-Bao Xu
Apr 12, 2012·Peptides·Ben-Shmuel SaritFleisher-Berkovich Sigal
Jun 15, 2011·Biochemical and Biophysical Research Communications·Yasuhiko SuzukiAkifumi Togari
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Jan 24, 2018·International Journal of Molecular Sciences·Erika TerzuoliMarina Ziche
Oct 12, 2012·American Journal of Physiology. Cell Physiology·Marina DobrivojevićJochen R Hirsch
May 8, 2019·Biological & Pharmaceutical Bulletin·Min JiaCang-Bao Xu

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