Cabazitaxel regimens inhibit the growth of prostate cancer cells and enhances the anti-tumor properties of PEDF with various efficacy and toxicity

The Prostate
Courtney JarvisS Filleur

Abstract

Taxanes chemotherapies represent the major therapeutic alternative for symptomatic mCRPC. While docetaxel is the most commonly prescribed Taxane for mCRPC; cabazitaxel has been approved for patients unresponsive to docetaxel. Still mCRPC remains incurable and patients often experience severe side effects. Recently, the FIRSTANA trial first demonstrated the absence of superiority in overall survival between cabazitaxel and docetaxel in mCRPC patients. Inversely, different toxicity were reported suggesting that cabazitaxel may provide a first line treatment option for some patients urging for a deeper characterization of cabazitaxel mechanisms of action as well as a re-evaluation of cabazitaxel conventional dose and schedule. In this study, our goal was therefore to evaluate the anti-tumor efficacy of various cabazitaxel regimens delivered as monotherapy or in combination with PEDF, a known anti-angiogenic and anti-neoplastic agent. CRPC cells undergoing Taxane treatment were evaluated for cell proliferation, migration and death, and apoptosis using crystal violet staining, chemotaxis, cell cycle, and TUNEL assays. In vitro data were corroborated in CL1 CRPC xenografts where mice received intermittent or metronomic low-doses caba...Continue Reading

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Citations

Dec 20, 2019·Scientific Reports·Anette LangebäckSara Lööf
May 31, 2019·Chemical Biology & Drug Design·Serpil DemirciAyşegül Doğan
Aug 18, 2020·International Journal of Nanomedicine·Zhong WanHai Zhang
Nov 27, 2020·Cancers·Naomi BrookArun Dharmarajan
Mar 17, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ejaj AhmadSundeep Singh Saluja

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