Cabergoline-induced fibrosis of prolactinomas: a neurosurgical perspective

BMJ Case Reports
Niraj MohanTseng Tsai Yeo

Abstract

Presently, the standard of care for prolactinomas, a type of pituitary adenoma, is dopaminergic agents such as bromocriptine and cabergoline. However, dopaminergic agents may induce fibrosis of cardiac valves leading to valvular insufficiency, necessitating surgical treatment of prolactinoma. Fibrosis of prolactinoma can be induced by prolonged medical treatment with bromocriptine, and this usually occurs after years of treatment. In comparison to bromocriptine, there have been no reports of cabergoline-induced fibrosis of prolactinoma. There is a potential for greater emphasis to be placed on assessing the tumour consistency from preoperative MRI scans, or even preoperative contrast-enhanced 3D Fast Imaging Employing Steady-state Acquisition imaging to allow better planning of the surgery. We report a rare case of fibrosis of prolactinoma after cabergoline treatment resulting in its subsequent difficult surgical removal. This patient had early MRI changes of fibrosis of prolactinoma after a short period of 6 months of cabergoline treatment.

References

May 1, 1992·Endocrine Reviews·J S BevanM F Scanlon
Dec 20, 1986·Nihon Naibunpi Gakkai zasshi·T TakahashiN Kageyama
Apr 1, 1985·The Journal of Clinical Endocrinology and Metabolism·M E MolitchM O Thorner
Jan 1, 1986·Journal of Neurosurgery·N HashimotoT Yamagami
Jun 1, 1996·Yonsei Medical Journal·Y G ParkS S Chung
Apr 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M E MolitchC Wilson
May 1, 1997·Neurosurgery·E Yaniv, Z H Rappaport
Nov 12, 1998·Acta neurochirurgica·T IuchiA Yamaura
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·J VerhelstA Beckers
Jun 1, 2001·Neurosurgery·J A JaneE R Laws
Jan 5, 2007·The New England Journal of Medicine·Renzo ZanettiniGianni Pezzoli
Sep 25, 2008·The Journal of Clinical Endocrinology and Metabolism·Masami OnoKazue Takano
Sep 30, 2010·Pituitary·Maria MenucciRoberto Salvatori
Aug 16, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Fatih GürbüzSerhan Küpeli

❮ Previous
Next ❯

Citations

Jun 1, 2021·Frontiers in Endocrinology·Lukas Andereggen, Emanuel Christ
Jun 21, 2021·Hormones : International Journal of Endocrinology and Metabolism·Alberto Acitores CancelaPedro Iglesias
Nov 8, 2018·Neuroendocrinology·Ilan Shimon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Shrikrishna V AcharyaNalini S Shah
Zhonghua hu li za zhi = Chinese journal of nursing
Y Zhong, B N Yuang
© 2022 Meta ULC. All rights reserved