Cabergoline treatment in prolactinoma: Amelioration in obstructive and central sleep apneas

Journal of Postgraduate Medicine
M BinarH Arslan

Abstract

A 44-year-old male patient was admitted to the otolaryngology department with a history of progressive snoring, excessive daytime sleepiness, and reduced libido for the last 6 months. Polysomnography demonstrated the presence of moderate obstructive sleep apnea (OSA) with an apnea-hypopnea index (AHI) of 24.6 events/h, consisting of 77 obstructive and 59 central apneas. The marked number of central apneas in the sleep study and urologic complaints prompted the performance of brain magnetic resonance imaging (MRI), which indicated a pituitary macroadenoma (prolactinoma). Three months after treatment with cabergoline, a control MRI showed a significant reduction in the size of the macroadenoma. The AHI was also significantly decreased (to 11.6 events/h), as were the numbers of obstructive and central apneas. The patient's complaints regarding libido were also regressed. During this treatment period, CPAP therapy has not been tolerated by the patient. Cabergoline treatment reduced the severity of both obstructive and central sleep apneas in this patient.

References

Oct 14, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jamie Chung Mei LamMary Sau Man Ip
Aug 1, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Meghan WoughterCristina M Baldassari
Apr 5, 2016·Indian Journal of Endocrinology and Metabolism·Nazir Ahmad PalaTariq A Dar
Nov 2, 2016·The European Respiratory Journal·Louis-Marie GalerneauUNKNOWN scientific council and investigators of the French national sleep apnoea registry (OSFP)

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