Cabin1 expression suggests roles in neuronal development

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Dena R Hammond, Ava J Udvadia

Abstract

Nervous system assembly and function depends on precise regulation of developmental gene expression. Cabin1, an essential gene in developing mice, is enriched in regions of the developing zebrafish central nervous system (CNS). Cabin1 is a repressor of MEF2- (myocyte enhancer factor 2) and calcineurin-mediated transcription in the immune system, but its function in the CNS during development is unknown. We identified Cabin1 from a library of genes enriched in developing neurons and determined the temporal and spatial expression of Cabin1 mRNA during CNS development. We found Cabin1 mRNA expression in the developing brain at times correlated with later aspects of neuronal differentiation. In some regions of the CNS Cabin1 expression overlaps with regions that also express proteins known to interact with Cabin1: MEF2 and/or calcineurin. We suggest that Cabin1 could act as a regulator of MEF2 and calcineurin activity in the developing nervous system, given their roles in neuronal differentiation and synaptic refinement.

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Citations

Dec 27, 2015·Archives of Biochemistry and Biophysics·Andreia AdriãoM Leonor Cancela
Sep 25, 2015·Journal of Receptor and Signal Transduction Research·Yueqiang WenJianbo Liang
Jan 17, 2015·Behavioural Brain Research·Danielle E CliftRobbert Creton
Apr 1, 2017·Cellular and Molecular Life Sciences : CMLS·Ya-Long Wang, Claire Xi Zhang
Jan 26, 2018·International Urology and Nephrology·Yueqiang WenJianbo Liang
Feb 1, 2020·Journal of Receptor and Signal Transduction Research·Yueqiang WenJianbo Liang
Nov 28, 2020·Developmental Biology·Duvaraka Kula-AlwarYaniv Hinits

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