CACG: a database for comparative analysis of conjoined genes

Genomics
Dae-Soo KimHong-Seog Park

Abstract

A conjoined gene is defined as one formed at the time of transcription by combining at least part of one exon from each of two or more distinct genes that lie on the same chromosome, in the same or opposite orientation, which translate independently into different proteins. We comparatively studied the extent of conjoined genes in thirteen genomes by analyzing the public databases of expressed sequence tags and mRNA sequences using a set of computational tools designed to identify conjoined genes on the same DNA strand or opposite DNA strands of the same genomic locus. The CACG database, available at http://cgc.kribb.re.kr/map/, includes a number of conjoined genes (7131-human, 2-chimpanzee, 5-orangutan, 57-chicken, 4-rhesus monkey, 651-cow, 27-dog, 2512-mouse, 263-rat, 1482-zebrafish, 5-horse, 29-sheep, and 8-medaka) and is very effective and easy to use to analyze the evolutionary process of conjoined genes when comparing different species.

References

Oct 23, 2004·Science·UNKNOWN ENCODE Project Consortium
Nov 9, 2007·Genome Research·Adam SiepelMichael R Brent

❮ Previous
Next ❯

Citations

Sep 5, 2014·Omics : a Journal of Integrative Biology·Guoping RenYong-Jie Lu
Jun 21, 2016·Cancer Letters·Fujun QinHui Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angelman Syndrome

Angelman syndrome is a neurogenetic imprinting disorder caused by loss of the maternally inherited UBE3A gene and is characterized by generalized epilepsy, limited expressive speech, sleep dysfunction, and movement disorders. Here is the latest research.