Cachectic Cancer Patients: Immune to Checkpoint Inhibitor Therapy?

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Christopher C CossMitch A Phelps

Abstract

Immune checkpoint inhibition is dramatically improving patient outcomes in diverse cancers, many of which responded poorly to traditional cytotoxic agents. Drivers of heterogeneous response to immune checkpoint therapy are poorly characterized. Cachectic cancer patients exhibit elevated pembrolizumab clearance and poor response, highlighting the immense therapeutic challenge posed by cancer cachexia.See related article by Turner et al., p. 5841.

References

Apr 12, 2017·Trends in Molecular Medicine·Thomas R FlintTobias Janowitz
Jun 28, 2017·CPT: Pharmacometrics & Systems Pharmacology·Josiah T Ryman, Bernd Meibohm
Jan 19, 2018·Nature Reviews. Disease Primers·Vickie E BaracosKenneth C H Fearon
Jun 13, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David C TurnerJulie A Stone

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Citations

Nov 7, 2019·International Journal of Molecular Sciences·Rami ArchidRobert B Wilson
Dec 11, 2019·Cancers·Anirban Roy, Ashok Kumar
Feb 11, 2020·Antioxidants & Redox Signaling·Fabio PennaPaola Costelli
May 16, 2020·Current Oncology Reports·Rishi JainDwight H Owen
Apr 30, 2020·Lung Cancer Management·Chung-Shien LeeNagashree Seetharamu
Mar 6, 2019·Frontiers in Physiology·Fabio PennaPaola Costelli
May 10, 2020·British Journal of Clinical Pharmacology·Vishal NavaniAndre Van Der Westhuizen
Apr 11, 2021·Journal for Immunotherapy of Cancer·Brendan D CurtiWilliam L Redmond
Jun 16, 2021·Pharmacology Research & Perspectives·Vishal NavaniAndre van der Westhuizen

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