Cachexia, a Systemic Disease beyond Muscle Atrophy.

International Journal of Molecular Sciences
Elisabeth WyartPaolo E Porporato

Abstract

Cachexia is a complication of dismal prognosis, which often represents the last step of several chronic diseases. For this reason, the comprehension of the molecular drivers of such a condition is crucial for the development of management approaches. Importantly, cachexia is a syndrome affecting various organs, which often results in systemic complications. To date, the majority of the research on cachexia has been focused on skeletal muscle, muscle atrophy being a pivotal cause of weight loss and the major feature associated with the steep reduction in quality of life. Nevertheless, defining the impact of cachexia on other organs is essential to properly comprehend the complexity of such a condition and potentially develop novel therapeutic approaches.

References

Aug 1, 1978·British Journal of Cancer·B JasaniG S Sokhi
Jan 1, 1976·Advances in Enzyme Regulation·E Ishikawa
Aug 1, 1992·Journal of the American College of Nutrition·J A Tayek
Jul 15, 1992·Biochemical and Biophysical Research Communications·I HardardóttirC Grünfeld
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P MatthysA Billiau
Aug 19, 1991·International Journal of Cancer. Journal International Du Cancer·P MatthysA Billiau
Jun 1, 1990·The American Journal of Physiology·L C FernandesR Curi
Jun 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B A SherryL L Moldawer
Mar 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A A JakubowskiH F Oettgen
Mar 1, 1988·The Journal of Infectious Diseases·K J TraceyA Cerami
Nov 1, 1995·The American Journal of Physiology·H D McCarthyG Williams
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·G S HotamisligilB M Spiegelman
Aug 1, 1993·The British Journal of Surgery·J PermertJ Larsson
Sep 18, 1997·Nutrition·P Matthys, A Billiau
Apr 4, 1998·Annals of Surgery·W H HartlF W Schildberg
Jan 29, 2000·The American Journal of Clinical Nutrition·S Leij-HalfwerkJ P Wilson
Jul 14, 2001·Molecular and Cellular Endocrinology·R Sakai, Y Eto
Apr 23, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·T SatoK Hatakeyama
Jan 10, 2004·Integrative Cancer Therapies·D Barry Boyd
Apr 16, 2004·The New England Journal of Medicine·G David Roodman
Feb 17, 2005·The Journal of Clinical Endocrinology and Metabolism·Josè M GarciaMarco Marcelli
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francesco GrazianoMauro Magnani
Jan 24, 2006·Archives of Disease in Childhood·M Druce, S R Bloom
Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Paul MonkMiguel A Villalona-Calero
May 18, 2006·American Journal of Physiology. Endocrinology and Metabolism·Satoshi FujitaElena Volpi
May 26, 2007·Endocrinology·Jarrad M ScarlettDaniel L Marks
Aug 19, 2007·Cell·Na Kyung LeeGerard Karsenty
Oct 18, 2007·Diabetes·Sandra PereiraRéjeanne Gougeon
Nov 27, 2007·FEBS Letters·William P Cawthorn, Jaswinder K Sethi
Dec 7, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kristen A BaltgalvisJames A Carson
Dec 9, 2008·Current Opinion in Supportive and Palliative Care·Nathan A StephensKenneth C H Fearon
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Jaap MulderFolkert Kuipers

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NCT03881826

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