Cachexia and advanced dementia

Journal of Cachexia, Sarcopenia and Muscle
Cecilia MinagliaFiammetta Monacelli

Abstract

Cachexia is a complex metabolic process that is associated with several end-stage organ diseases. It is known to be also associated with advanced dementia, although the pathophysiologic mechanisms are still largely unknown. The present narrative review is aimed at presenting recent insights concerning the pathophysiology of weight loss and wasting syndrome in dementia, the putative mechanisms involved in the dysregulation of energy balance, and the interplay among the chronic clinical conditions of sarcopenia, malnutrition, and frailty in the elderly. We discuss the clinical implications of these new insights, with particular attention to the challenging question of nutritional needs in advanced dementia and the utility of tube feeding in order to optimize the management of end-stage dementia.

References

Apr 1, 1976·Archives of Neurology·H LijtmaerR Katzman
Jan 1, 1992·International Psychogeriatrics·G P Wolf-KleinA P Levy
Apr 1, 1992·Archives of Neurology·D P DevanandY Stern
Jun 1, 1992·Journal of the American College of Nutrition·C T HendersonT P Miles
Nov 1, 1990·Journal of the American Geriatrics Society·A PeckM N Mulvihill
Mar 1, 1983·American Journal of Medical Genetics·P S Moorhead, A Heyman
Apr 1, 1995·Journal of the American Geriatrics Society·T E Finucane
May 1, 1996·Journal of General Internal Medicine·L RabeneckN J Petersen
Oct 1, 1996·Journal of the American Geriatrics Society·K E DonaldsonE T Poehlman
Mar 1, 1997·Archives of General Psychiatry·D P DevanandY Stern
Oct 10, 1997·The American Journal of Clinical Nutrition·J E Morley
Nov 15, 1997·Journal of the American Geriatrics Society·G Reyes-OrtegaL J Fitten
Oct 20, 1999·JAMA : the Journal of the American Medical Association·T E FinucaneK Travis
Oct 20, 1999·JAMA : the Journal of the American Medical Association·R McCann
Jan 20, 2000·The New England Journal of Medicine·M R Gillick
Apr 20, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·M A RudbergJ A Brody
Sep 13, 2000·Journal of the American Geriatrics Society·C M CallahanR Nisi
Dec 29, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S L Mitchell, J M Tetroe
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
May 30, 2001·Molecular and Cellular Endocrinology·W Q Zhao, D L Alkon
Mar 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wesley FarrisSuzanne Guenette
Jun 11, 2003·Archives of Internal Medicine·Lynne M Murphy, Timothy O Lipman
Aug 9, 2003·Neuroimmunomodulation·Alberto D IntebiEduardo Spinedi
Mar 20, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Linda P FriedGerard Anderson
Apr 20, 2004·European Journal of Pharmacology·G Stennis Watson, Suzanne Craft
Jun 10, 2004·JAMA : the Journal of the American Medical Association·Susan L MitchellBrant E Fries
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takeshi ShiikiTetsuya Terasaki
Mar 31, 2005·International Journal of Geriatric Psychiatry·Baldomero Alvarez-FernándezRicardo Gómez-Huelgas
Aug 19, 2006·Alzheimer Disease and Associated Disorders·Susan L MitchellJoan M Teno
Sep 13, 2006·Archives of Neurology·David K JohnsonJohn C Morris
Jan 19, 2007·Behavioural Brain Research·Perdita L PughDavid Sunter
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth RockwoodArnold Mitnitski
Aug 19, 2007·Experimental Gerontology·M BarbieriM Varricchio
Dec 12, 2007·Archives of Neurology·Nikolaos ScarmeasYaakov Stern
Jun 3, 2008·Behavioral Neuroscience·Ellen VloeberghsPeter Paul De Deyn
Jun 3, 2008·Behavioral Neuroscience·Dave Morgan, Marcia N Gordon
Jul 11, 2008·The Journal of Nutrition, Health & Aging·J E Morley
Aug 23, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·William J EvansStefan D Anker
Sep 16, 2008·Journal of Palliative Medicine·Paola Di GiulioPatrizia Spadin

❮ Previous
Next ❯

Citations

Dec 24, 2019·Journal of Parkinson's Disease·Keisuke SuzukiKoichi Hirata
Jun 20, 2020·Journal of Cachexia, Sarcopenia and Muscle·Shih-Tsung HuangLiang-Kung Chen
May 18, 2020·Journal of the American Geriatrics Society·Neema ShardaKimberly S Johnson
Nov 12, 2020·Clinical Interventions in Aging·Helena KrysztofiakMarta Kałużna-Oleksy
Nov 19, 2020·International Journal of Environmental Research and Public Health·Yu-Ming WuYing-Hsuan Tai
May 15, 2021·Clinical Diabetes : a Publication of the American Diabetes Association·Kate Zachary, Natalie Dawn Ritchie

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cachexia, Sarcopenia and Muscle
Karin J C SandersAnnemie M W J Schols
Journal of the American Medical Directors Association
John E Morley, David R Thomas
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Giovanni Mantovani, Clelia Madeddu
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
Atsushi Araki
Current Opinion in Clinical Nutrition and Metabolic Care
Judith de Vos-GeelenAnnemie M W J Schols
© 2022 Meta ULC. All rights reserved