Cachexia Stage, Patient-Generated Subjective Global Assessment, Phase Angle, and Handgrip Strength in Patients with Gastrointestinal Cancer

Nutrition and Cancer
Gislaine Aparecida OzorioNora Manoukian Forones

Abstract

The aim of this study was to correlate patients with gastrointestinal cancer, classified according to different stages of cancer cachexia (SCC) as proposed by Fearon, with nutritional assessment tools such as PG-SGA, phase angle (PA), and handgrip strength. One hundred one patients with a mean age of 61.8 ± 12.8 yr, with 58.4% being men were included. 32.6% were malnourished according to the body mass index (BMI). A severe or moderate malnutrition had been diagnosed in 63.3% when assessed using the PG-SGA, 60.4% had decreased handgrip strength, and 57.4% had lower grades of PA. Among the patients in the study, 26% did not have cachexia, 11% had precachexia, 56% cachexia, and 8% refractory cachexia. The PG-SGA, PA, and handgrip strength were associated with cachexia (P ≤ 0.001). An increased risk of death was found in patients with cachexia [RR: 9.1; confidence interval (CI) 95%: 0.1-90.2, P = 0.039], refractory cachexia (RR: 69.4, CI 95%: 4.5-1073.8, P = 0.002), and increased serum C-reactive protein (CRP) levels (P < 0.001). In conclusion, most of the patients with digestive system cancer had cachexia or refractory cachexia in the first nutritional assessment. Nutritional risk, as determined by PG-SGA, was correlated with PA a...Continue Reading

References

Jun 6, 2000·Critical Reviews in Oncology/hematology·G Nitenberg, B Raynard
Dec 31, 2002·Journal of Pain and Symptom Management·Kristine A Nelson, Declan Walsh
Dec 3, 2003·The American Journal of Hospice & Palliative Care·Nabeel SarhillAdnan Tahir
Dec 9, 2004·The American Journal of Clinical Nutrition·Digant GuptaChristopher G Lis
Apr 6, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Christopher Deans, Stephen J Wigmore
Apr 6, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Maria Cristina G Barbosa-Silva, Aluísio J D Barros
May 17, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kristina NormanMatthias Pirlich
Jul 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kenneth C H FearonGordon D Murray
Feb 29, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Malgorzata Krzystek-KorpackaAndrzej Gamian
Apr 1, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K C H Fearon
Mar 26, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Donald C McMillan
Jan 12, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M MuscaritoliC C Sieber
Jan 16, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·David BlumUNKNOWN European Palliative Care Research Collaborative
Jul 16, 2010·The American Journal of Clinical Nutrition·Kristina NormanMatthias Pirlich
Aug 10, 2010·Current Opinion in Supportive and Palliative Care·Alessio MolfinoFilippo Rossi Fanelli
Jan 11, 2011·Critical Reviews in Oncology/hematology·David BlumUNKNOWN European Palliative Care Research Collaborative
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
Mar 23, 2011·Current Problems in Cancer·Norleena P GullettThomas R Ziegler
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Robert D KilgourJosé A Morais
Jul 19, 2011·Journal of Cachexia, Sarcopenia and Muscle·Vickie E Baracos
Oct 12, 2011·Current Opinion in Supportive and Palliative Care·David Blum, Florian Strasser
Jul 25, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·K C H Fearon
Apr 22, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Xavier HébuterneFrançois Goldwasser

❮ Previous
Next ❯

Citations

Oct 31, 2017·Nutrition and Cancer·Dana A Pérez CamargoVíctor I Urbalejo Ceniceros
Jun 6, 2021·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·Lauren CarmichaelNicole Kiss
Sep 14, 2021·Nutrición hospitalaria·Nadia Denisse Ramírez MartínezJaime Arturo Guel Pañola

❮ Previous
Next ❯

Software Mentioned

R Core
MASS
R

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

© 2022 Meta ULC. All rights reserved