Cad74A is regulated by BR and is required for robust dorsal appendage formation in Drosophila oogenesis.

Developmental Biology
Jeremiah J ZartmanStanislav Y Shvartsman

Abstract

Drosophila egg development is an established model for studying epithelial patterning and morphogenesis, but the connection between signaling pathways and egg morphology is still incompletely understood. We have identified a non-classical cadherin, Cad74A, as a putative adhesion gene that bridges epithelial patterning and morphogenesis in the follicle cells. Starting in mid-oogenesis, Cad74A is expressed in the follicle cells that contact the oocyte, including the border cells and most of the columnar follicle cells. However, Cad74A is repressed in two dorsolateral patches of follicle cells, which participate in the formation of tubular respiratory appendages. We show genetically that Cad74A is downstream of the EGFR and BMP signaling pathways and is repressed by the Zn-finger transcription factor Broad. The correlation of Cad74A repression in the cells that bend out of the plane of the follicular epithelium is preserved across Drosophila species and mutant backgrounds exhibiting a range of eggshell phenotypes. Complete removal of Cad74A from the follicle cells causes defects in dorsal appendage formation. Ectopic expression of Cad74A in the roof cells results in shortened, flattened appendages due to the hindered migration of ...Continue Reading

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Citations

Feb 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jessica LembongStanislav Y Shvartsman
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lily S CheungStanislav Y Shvartsman
Sep 27, 2008·Gene Expression Patterns : GEP·Jeremiah J ZartmanStanislav Y Shvartsman
Jul 28, 2010·Developmental Biology·Michael J BoyleCeleste A Berg
Aug 25, 2011·Current Opinion in Genetics & Development·Lily S CheungStanislav Y Shvartsman
Mar 2, 2013·Developmental Cell·Miriam OsterfieldStanislav Y Shvartsman
Nov 13, 2008·Developmental Cell·Nir YakobyStanislav Y Shvartsman
Mar 16, 2011·Developmental Biology·Matthew G NiepielkoNir Yakoby
Jan 1, 2013·Developmental Biology·Robert A MarmionNir Yakoby
Jan 1, 2010·Annual Review of Chemical and Biomolecular Engineering·Jeremiah J Zartman, Stanislav Y Shvartsman
Jun 22, 2017·G3 : Genes - Genomes - Genetics·Nicole T RevaitisNir Yakoby
Feb 10, 2021·G3 : Genes - Genomes - Genetics·Miles W DeAngelisRuth I Johnson
May 9, 2015·Development·Miriam OsterfieldStanislav Y Shvartsman

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