PMID: 8494430May 1, 1993Paper

Cadaver lung donors: effect of preharvest ventilation on graft function

The Annals of Thoracic Surgery
K S UlicnyB R Wilcox

Abstract

The pulmonary donor pool would increase substantially if lungs could be safely transplanted after cessation of circulation. To determine whether ventilation of cadaver lungs could improve graft function, canine donors were sacrificed and then ventilated with 100% oxygen (n = 6) or 100% nitrogen (n = 6); 6 served as nonventilated controls. Four hours after death, the lungs were flushed with modified Euro-Collins solution and harvested. Controls were ventilated with 100% oxygen only during flush and harvest. Recipients were rendered dependent on the transplanted lung by occlusion of the right pulmonary artery and bronchus 1 hour after transplantation. Ventilation was maintained at a constant inspired oxygen fraction of 0.4. Four controls died of pulmonary edema shortly after occlusion of the native lung. The mean arterial oxygen tensions in the oxygen-ventilated, nitrogen-ventilated, and control groups at the end of 8 hours were 81 mm Hg (n = 4), 88 mm Hg (n = 3), and 55 mm Hg (n = 2), respectively. Postmortem oxygen ventilation improved early recipient survival and gas exchange. Postmortem nitrogen ventilation improved early gas exchange and delayed recipient death compared with non-ventilated controls. The mechanics of ventilat...Continue Reading

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Citations

Aug 1, 1996·The Annals of Thoracic Surgery·D E Van RaemdonckT E Lerut
Aug 17, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Pablo GámezUNKNOWN Lung Transplant Group of the Puerta de Hierro Hospital
Jan 13, 2001·The Annals of Thoracic Surgery·R NakanishiK Yasumoto
Feb 5, 2004·The Annals of Thoracic Surgery·Filip R RegaDirk E M Van Raemdonck
Sep 2, 1998·The Annals of Thoracic Surgery·T M EganL J Paradowski
Oct 7, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R GrecoE De Miguel
Feb 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S OkimasaT Asahara
Feb 9, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Shi Ping LuhPan Chyr Yang
Jan 22, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Thomas M Egan
Dec 22, 1998·Annals of Surgery·D E Van RaemdonckT E Lerut
Apr 15, 1996·Transplantation·M H HenningtonT M Egan
May 20, 2015·Scandinavian Cardiovascular Journal : SCJ·Leif PierreRichard Ingemansson
Mar 1, 2012·The Annals of Thoracic Surgery·Sven LehmannHartmuth B Bittner
Feb 7, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David Gomez-de-AntonioAndrés Varela
Feb 10, 2009·The Journal of Surgical Research·Caroline Van De WauwerDirk E M Van Raemdonck
Jul 29, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Daniel HodycJan Herget
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Jul 1, 1996·The Annals of Thoracic Surgery·R J NovickJ Lee
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Apr 17, 2003·The Journal of Thoracic and Cardiovascular Surgery·Makio HayamaNobuyoshi Shimizu
Sep 26, 2006·The Annals of Thoracic Surgery·Hidetoshi InokawaThomas M Egan
Nov 1, 1996·The Annals of Thoracic Surgery·A M D'ArminiT M Egan
Dec 3, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Eileen J BurkerThomas M Egan
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Jun 26, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·D E Van RaemdonckT E Lerut
Mar 19, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Dirk Van RaemdonckArne Neyrinck
Apr 16, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T M Egan, J J Requard

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