Cadaveric renal transplantation in hepatitis B antigen-positive recipients using hepatitis B antigen-positive donor organs with lamivudine treatment

Transplantation Proceedings
J A KimH-Y Oh

Abstract

Although renal transplantation has been regarded as the best renal replacement therapy in end-stage renal disease patients, there have never been enough organ donors. Therefore, hepatitis B surface antigen (HBsAg)-negative patients are often given priority over HBsAg-positive patients. We performed cadaveric renal transplantation in six HBsAg-positive recipients given HBsAg-positive donor organs who were on lamivudine treatment. Donors were found to have normal renal function by serum and urine laboratory tests. All recipients underwent liver biopsies before transplantation; those with liver cirrhosis were excluded. All recipients were treated with 100 mg lamivudine once daily because of positive titers of hepatitis B viral (HBV) DNA (three patients), and increased levels of alanine aminotransferase (ALT) (three patients). During the follow-up period, one patient died from hepatic failure at 50 months after transplantation without deterioration of graft function. The remaining five patients showed sustained normal ALT levels. Decreases in HBV DNA titer were observed among patients who were positive before transplantation, but did not reverse to negative. Acute rejection developed in two patients: one was treated successfully wi...Continue Reading

References

Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J L DienstagN Brown

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Citations

Nov 14, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·V T YilmazH Kocak
Jun 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H JiangJ Chen
Oct 27, 2015·Journal of the Pediatric Infectious Diseases Society·Rebecca L RuebnerBenjamin L Laskin
Oct 25, 2016·Seminars in Nephrology·Kiran Gajurel, Jack T Stapleton
Mar 21, 2012·Transplantation·Helen L Pilmore, Edward J Gane
Apr 29, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Massimiliano VerouxPierfrancesco Veroux

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