Cadherin-11 promotes the metastasis of prostate cancer cells to bone.

Molecular Cancer Research : MCR
Khoi ChuSue-Hwa Lin

Abstract

Bone is the most common site of metastases from prostate cancer. The mechanism by which prostate cancer cells metastasize to bone is not fully understood, but interactions between prostate cancer cells and bone cells are thought to initiate the colonization of metastatic cells at that site. Here, we show that cadherin-11 (also known as osteoblast-cadherin) was highly expressed in prostate cancer cell line derived from bone metastases and had strong homophilic binding to recombinant cadherin-11 in vitro. Down-regulation of cadherin-11 in bone metastasis-derived PC3 cells with cadherin-11-specific short hairpin RNA (PC3-shCad-11) significantly decreased the adhesion of those cells to cadherin-11 in vitro. In a mouse model of metastasis, intracardiac injection of PC3 cells led to metastasis of those cells to bone. However, the incidence of PC3 metastasis to bone in this model was reduced greatly when the expression of cadherin-11 by those cells was silenced. The clinical relevance of cadherin-11 in prostate cancer metastases was further studied by examining the expression of cadherin-11 in human prostate cancer specimens. Cadherin-11 was not expressed by normal prostate epithelial cells but was detected in prostate cancer, with it...Continue Reading

References

Apr 1, 1983·Urology·S C Jacobs
Feb 5, 1998·Journal of the National Cancer Institute·J E Lehr, K J Pienta
Oct 26, 1999·Urologia Internationalis·K TozawaK Kohri
Dec 8, 2000·The Journal of Biological Chemistry·M Orlandini, S Oliviero
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J KawaguchiA Kudo
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J KawaguchiA Kudo
Oct 2, 2003·Current Opinion in Cell Biology·Margaret J Wheelock, Keith R Johnson
Oct 4, 2003·Clinical & Experimental Metastasis·Gabriele CarlinfanteGöran Andersson
Mar 3, 2004·Journal of Cellular Biochemistry·Kwanchanit TantivejkulKenneth J Pienta
Mar 27, 2004·Cancer Treatment and Research·Shi-Ming Tu, Sue-Hwa Lin
May 4, 2004·International Journal of Cancer. Journal International Du Cancer·Robert A SikesLeland W K Chung
Nov 20, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ilaria RoatoRiccardo Ferracini
Jan 5, 2005·Nature Reviews. Cancer·Christopher J Logothetis, Sue-Hwa Lin
Sep 6, 2005·Cancer Research·Christopher L HallEvan T Keller
Jan 21, 2006·Cancer Research·Ani C KhodavirdiPradip Roy-Burman
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman
Sep 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gabriel MbalavieleRoberto Civitelli
May 9, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Todd M MorganRobert L Vessella

❮ Previous
Next ❯

Citations

Aug 10, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Anjali MishraRussell S Taichman
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Geert Berx, Frans van Roy
Dec 10, 2009·Cancer Research·Mohit Sachdeva, Yin-Yuan Mo
Jun 15, 2011·Molecular Cancer Research : MCR·Andrew J ArmstrongMariano A Garcia-Blanco
Jan 24, 2012·Molecular Cancer Research : MCR·Harpreet KaurSusann M Brady-Kalnay
Mar 4, 2014·PloS One·Robert L SatcherSue-Hwa Lin
Oct 22, 2013·Pharmacology & Therapeutics·Mark Esposito, Yibin Kang
Feb 11, 2014·Clinical & Experimental Metastasis·Parisa HesamiJudith A Clements
Feb 27, 2016·BoneKEy Reports·Jinlu DaiYusuke Shiozawa
Feb 18, 2016·Developmental Biology·Chaolie HuangJubin Kashef
Sep 10, 2014·Journal of Drug Targeting·Tejinder SinghRavindra K Rawal
Jul 3, 2015·Oncology Letters·Mateusz BujkoJanusz Aleksander Siedlecki
Feb 9, 2011·Biochemical Pharmacology·J Wang, P H Stern
Dec 17, 2009·Cancer Letters·Yunfei ZhangQingyu Fan
Oct 20, 2009·European Journal of Pharmacology·Orest W Blaschuk, Emmanuelle Devemy
Sep 19, 2015·Cancer Biology & Therapy·Leila KokabeeDouglas S Conklin
May 31, 2012·The Prostate·Bhavani KrishnanPatricia E Gallagher
Mar 27, 2010·International Journal of Cancer. Journal International Du Cancer·Marilena VeredTuula Salo
Jan 17, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sherry G ClendenonJames A Marrs
Mar 1, 2012·The Journal of Pathology·F Javier CarmonaManel Esteller
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Jung-Kang JinGary E Gallick
Jan 29, 2010·Cancer·Toni IbrahimDino Amadori
Mar 2, 2010·The Journal of Pathology·Yu-Chen LeeSue-Hwa Lin
Mar 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fernando Vázquez-VillaJuan R de Los Toyos
Jul 15, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zbigniew LorencUrszula Mazurek
Jan 13, 2015·International Journal of Cell Biology·Mehdi DehghaniZohreh Mostafavi-Pour
Jun 21, 2015·Clinical & Experimental Metastasis·Mihoko HatanoYukihide Iwamoto
May 13, 2015·Trends in Pharmacological Sciences·Jing Y Krzeszinski, Yihong Wan
Jan 29, 2014·JAK-STAT·Mulu GeletuLeda Raptis
Jan 31, 2012·Medical Hypotheses·Janaina FernandesClaudia de Alencar S Lage
Apr 2, 2013·Biochimica Et Biophysica Acta·M GeletuL Raptis
Jun 28, 2011·The American Journal of Pathology·Lichao SunYuliang Ran

❮ Previous
Next ❯

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