Cadherin-13 gene is associated with hyperactive/impulsive symptoms in attention/deficit hyperactivity disorder

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Angelica Salatino-OliveiraMara H Hutz

Abstract

Several efforts have been made to find new genetic risk variants which explain the high heritability of ADHD. At the genome level, genes involved in neurodevelopmental pathways were pointed as candidates. CDH13 and CTNNA2 genes are within GWAS top hits in ADHD and there are emerging notions about their contribution to ADHD pathophysiology. The main goal of this study is to test the association between SNPs in CDH13 and CTNNA2 genes and ADHD across the life cycle in subjects with ADHD. This study included 1,136 unrelated ADHD cases and 946 individuals without ADHD. No significant association between CDH13 and CTNNA2 was observed between cases and controls across different samples (P ≥ 0.096 for all comparisons). No allele was significantly more transmitted than expected from parents to ADHD probands. The CDH13 rs11150556 CC genotype was associated with more hyperactive/impulsive symptoms in youths with ADHD (children/adolescents clinical sample: F = 7.666, P = 0.006, FDR P-value = 0.032; Pelotas Birth Cohort sample: F = 6.711, P = 0.011, FDR P-value = 0.032). Although there are many open questions regarding the role of neurodevelopmental genes in ADHD symptoms, the present study suggests that CDH13 is associated with hyperactive...Continue Reading

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Citations

Dec 15, 2015·Expert Review of Neurotherapeutics·Glaucia Chiyoko Akutagava-MartinsMara Helena Hutz
Jan 18, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Cristian BonviciniCatia Scassellati
Apr 8, 2017·Genes, Brain, and Behavior·C P KingP J Meyer
Apr 8, 2017·Brain Structure & Function·Abigail C KillenWilliam D Andrews
Jul 3, 2020·Soa--chʻŏngsonyŏn Chŏngsin Ŭihak = Journal of Child & Adolescent Psychiatry·Geon Ho BahnYoo-Sook Joung
Sep 19, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ziarih HawiMark A Bellgrove
Jan 27, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Natàlia Pujol-GualdoMaría Soler Artigas

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