PMID: 11718832Nov 24, 2001

Cadherin-4 expression in the zebrafish central nervous system and regulation by ventral midline signaling

Brain Research. Developmental Brain Research
Qin LiuP A Raymond

Abstract

In this study we show that zebrafish cadherin-4 (R-cadherin) transcript (cad4) and protein are expressed in several defined regions in the embryonic forebrain and in distinctive clusters in the hindbrain and spinal cord. This is the first report of a segmental pattern of expression of cadherin-4 in the hindbrain and spinal cord. Expression domains of cadherin-4 transcript and protein were compared with that of pax6.1. In the forebrain of zebrafish embryos, cad4 and pax6.1 expression domains overlapped extensively, although they were not completely coincident. Injection of pax6.1 mRNA resulted in an increase in cad4 expression, whereas overexpression of sonic hedgehog (shh), a midline signaling molecule that reduces pax6.1 expression, caused a reduction in cad4 expression throughout the brain. cad4 expression was increased in both forebrain and hindbrain in cyclops mutant embryos, which have a defect in midline signaling and an enlarged expression domain of pax6.1. These results suggest that zebrafish cadherin-4 may play a role in organization of neuronal architecture throughout the neural axis, and that its expression is regulated by a ventral midline signaling pathway that involves shh and pax6.1.

References

Jul 31, 2008·Cell and Tissue Research·Qin LiuAmy L Wilson
Jan 7, 2004·Journal of Physiology, Paris·Christoph RediesJiankai Luo
Jun 12, 2003·Gene Expression Patterns : GEP·Z M NovinceQin Liu
Jul 21, 2009·Gene Expression Patterns : GEP·Qin LiuTohru Murakami
Dec 13, 2006·Molecular and Cellular Neurosciences·Pontus C HolmMagdalena Götz
May 18, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Qin LiuJ A Marrs
May 6, 2004·Brain Research. Developmental Brain Research·Qin LiuA L Wilson
May 27, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sherry G BabbJ A Marrs
Jun 18, 2010·Developmental Neurobiology·Elisabeth Rungger-BrändleDuri Rungger
Feb 15, 2014·Cell Adhesion & Migration·Alicia F PaulsonPasquale Manzerra
Mar 6, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bettina ErdmannMargret I Moré
Dec 4, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Qin LiuJ A Marrs
Sep 16, 2004·The Journal of Comparative Neurology·Qin LiuLala Hashmi
Aug 29, 2012·Developmental Neurobiology·Yun ChenQin Liu
May 29, 2008·Developmental Neurobiology·Qin LiuDavid G Fatkins
Apr 27, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A E KerstetterQin Liu
Feb 7, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Amy L WilsonQin Liu

Citations

Sep 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L K Barthel, P A Raymond
May 1, 1990·Neuron·B TrevarrowC B Kimmel
Sep 8, 1986·The Journal of Comparative Neurology·B Mendelson
Oct 1, 1993·Journal of Neurobiology·R KrumlaufA Lumsden
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·K HattaC B Kimmel
Jan 1, 1993·Annual Review of Neuroscience·C B Kimmel
Jun 17, 1993·Nature·M C Figdor, C D Stern
Jan 1, 1997·Journal of Neurobiology·N Hirsch, W A Harris
Oct 10, 1997·Cell and Tissue Research·Christoph Redies
Apr 25, 2000·Progress in Neurobiology·Christoph Redies

Related Concepts

Embryo
Signaling Molecule
Hedgehog Proteins
Cdh4 protein, zebrafish
Malignant Neoplasm of Spinal Cord
CDH4 gene
Brain
Hindbrain
Signal Transduction Pathways
Entire Central Nervous System

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