PMID: 9536277Apr 16, 1998Paper

Cadherin and catenin biology represent a global mechanism for epithelial cancer progression

Molecular Pathology : MP
J A JankowskiD S Sanders

Abstract

The cell undergoes a diverse range of stimulations including growth factor activation and signal transduction from adhesion receptors, such as cadherins. In the absence of a mitogenic signal from outside the cell, beta catenin is sequestered in complexes with the product of the adenomatous polyposis coli (APC) gene and a serine threonine glycogen kinase (GSK 3 beta) enabling degradation of free beta catenin. Residual catenins hold cells together by binding to cadherins both at adherens junctions and the actin cytoskeleton. When a mitotic signal is delivered by the wnt pathway, GSK 3 beta is antagonised so that beta catenin can no longer be degraded. Cytosolic concentrations rise and binding to other newly synthesised proteins occurs, especially transcription factors that are transported to the nucleus, such as lymphocyte enhancing factor and T cell factor. This article discusses the signalling between mitogenic and adhesion pathways and suggests that it is a global mechanism for development, differentiation, and disease. These changes in catenin and APC biology may not be sufficient alone to transform cells fully but they appear to be a necessary final common pathway for several cancers of the mucous secreting crypts (including...Continue Reading

References

Dec 1, 1992·Seminars in Cell Biology·J A Jankowski, N A Wright
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Dec 10, 1993·Science·B RubinfeldP Polakis
May 1, 1996·Molecular and Cellular Biology·J PapkoffP Polakis
Apr 10, 1997·Nature·C LengauerB Vogelstein
Jul 1, 1996·Trends in Cell Biology·G I WelshC G Proud

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Citations

Sep 15, 2005·Cell and Tissue Research·Satdarshan P S MongaAaron Bell
Jan 15, 2004·Experimental Cell Research·Sunny Z HussainSatdarshan P S Monga
May 11, 1999·The American Journal of Pathology·J A JankowskiL S Young
Apr 17, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roy M BremnesWilbur A Franklin
Apr 19, 2003·Journal of Gastroenterology and Hepatology·Annie On-On ChanShiu-Kum Lam
Dec 4, 2002·BJU International·R T Bryan, D M A Wallace
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S P MongaG K Michalopoulos
Mar 10, 1999·Journal of Clinical Pathology·J M ReteraP H Theunissen
Nov 30, 2007·BMC Cancer·Marisa C L S GenelhuGeovanni D Cassali
Mar 18, 2008·Seminars in Cell & Developmental Biology·Buzz BaumMargaret P Quinlan
Jun 19, 2004·Pathology·Rooshdiya KarimSoon Lee
May 17, 2005·Journal of Hepatology·Dimple SodhiSatdarshan P S Monga
Oct 3, 2015·European Journal of Dentistry·Ugrappa SrideviStuti Goyal
Sep 24, 2011·Journal of Oncology·Takuji TanakaKoji Suzuki
Jun 28, 2011·The American Journal of Pathology·Lichao SunYuliang Ran
Nov 1, 2016·Antioxidants & Redox Signaling·Graciele Almeida de OliveiraDavid A Wink
Dec 13, 2005·Expert Review of Anticancer Therapy·Hashim Uddin AhmedHitendra R H Patel
Jul 2, 2003·The Annals of Otology, Rhinology, and Laryngology·Nikki JohnstonJames A Koufman
Aug 10, 2000·The British Journal of Surgery·B P WijnhovenM Pignatelli
Sep 5, 2001·The British Journal of Dermatology·T KageshitaT Ono
Dec 26, 2009·International Journal of Surgical Pathology·Chetana ChandrashekarRekha Krishnapillai
Jun 22, 2017·Journal of Neurogenetics·Mercedes Arnés, Sergio Casas Tintó
Jun 4, 2002·Nature Reviews. Molecular Cell Biology·Steven M Frisch, Joe S Mymryk
Mar 29, 2001·The Journal of Pathology·G Saldanha
Oct 18, 2006·International Journal of Cancer. Journal International Du Cancer·Stephanie Arndt, Anja K Bosserhoff
Aug 28, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Marisa C L S GenelhuGeovanni D Cassali
Sep 20, 2005·Oncogene·S KuphalA K Bosserhoff
Feb 24, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·D E AustF M Waldman
Mar 28, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·F PiardL Martin
Sep 24, 2004·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Cristina Faleiro-RodriguesCarlos Silva Lopes
Jan 3, 2001·The Journal of Clinical Endocrinology and Metabolism·J BöhmV M Kosma
May 7, 2019·Canadian Journal of Gastroenterology & Hepatology·Alexander DesukiCarl C Schimanski
Dec 19, 2001·BMC Cancer·C HuipingS Ingvarsson
Mar 20, 2004·The British Journal of Dermatology·A M Hassanein, S M Glanz

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