Cadherin dynamics during neural crest cell ontogeny

Progress in Molecular Biology and Translational Science
L A Taneyhill, Andrew T Schiffmacher

Abstract

Cell membrane-associated junctional complexes mediate cell-cell adhesion, intercellular interactions, and other fundamental processes required for proper embryo morphogenesis. Cadherins are calcium-dependent transmembrane proteins at the core of adherens junctions and are expressed in distinct spatiotemporal patterns throughout the development of an important vertebrate cell type, the neural crest. Multipotent neural crest cells arise from the ectoderm as epithelial cells under the influence of inductive cues, undergo an epithelial-to-mesenchymal transition, migrate throughout the embryonic body, and then differentiate into multiple derivatives at predetermined destinations. Neural crest cells change their expressed cadherin repertoires as they undergo each new morphogenetic transition, providing insight into distinct functions of expressed cadherins that are essential for proper completion of each specific stage. Cadherins modulate neural crest cell morphology, segregation, migration, and tissue formation. This chapter reviews the knowledge base of cadherin regulation, expression, and function during the ontogeny of the neural crest.

Citations

Jan 11, 2014·PloS One·Davina TondeleirChristophe Ampe
Feb 15, 2014·Cell Adhesion & Migration·Alicia F PaulsonPasquale Manzerra
May 6, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alwyn Dady, Jean-Loup Duband
Jan 26, 2018·Genesis : the Journal of Genetics and Development·Chaya Kalcheim
Aug 7, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Taylor GarmonShuyi Nie
Feb 25, 2015·Cell and Tissue Research·Liat SamuelovRalf Paus
Sep 18, 2014·Birth Defects Research. Part C, Embryo Today : Reviews·Dongcheng ZhangDonald Newgreen
Mar 3, 2017·Genesis : the Journal of Genetics and Development·L A Taneyhill, Andrew T Schiffmacher

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