Cadherins in cerebellar development: translation of embryonic patterning into mature functional compartmentalization

The Cerebellum
Christoph RediesJuntang Lin

Abstract

Cadherins are cell adhesion molecules with multiple morphogenic functions in brain development, for example, in neuroblast migration and aggregation, axon navigation, neural circuit formation, and synaptogenesis. More than 100 members of the cadherin superfamily are expressed in the developing and mature brain. Most of the cadherins investigated, in particular classic cadherins and δ-protocadherins, are expressed in the cerebellum. For several cadherin subtypes, expression begins at early embryonic stages and persists until mature stages of cerebellar development. At intermediate stages, distinct Purkinje cell clusters exhibit unique rostrocaudal and mediolateral expression profiles for each cadherin. In the chicken, mouse, and other species, the Purkinje cell clusters are separated by intervening raphes of migrating granule cells. This pattern of Purkinje cell clusters/raphes is, at least in part, continuous with the parasagittal striping pattern that is apparent in the mature cerebellar cortex, for example, for zebrin II/aldolase C. Moreover, subregions of the deep cerebellar nuclei, vestibular nuclei and the olivary complex also express cadherins differentially. Neuroanatomical evidence suggests that the nuclear subregions a...Continue Reading

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Related Concepts

Embryo
Myoclonic Epilepsies, Progressive
Cerebellar Nuclei
Aggregation
Purkinje Cells
Fetishism (Psychiatric)
Zebrin II
Neuroblast Migration
CDH17 gene
Structure of Cortex of Kidney

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