Cadmium affects toxicokinetics of pyrene in the collembolan Folsomia candida.

Ecotoxicology
Mieke BroerseCornelis A M van Gestel

Abstract

Since toxicity is time dependent, short-term toxicity tests may overlook mixture effects, because chemical accumulation within an organism takes time. We therefore studied the effects of cadmium on the toxicokinetics of pyrene and its metabolites in the soil-dwelling collembolan Folsomia candida exposed through Lufa 2.2 soil. Single pyrene was rapidly taken up and steady state was reached within the 337-h exposure period. Simultaneous exposure to cadmium significantly decreased the pyrene uptake and elimination rate, resulting in a prolonged half life. Kinetics of the first phase metabolite OH-pyrene was also significantly influenced by cadmium. Cadmium increased the hydroxylation rate of pyrene but slowed down its further metabolization, again resulting in a prolonged half life. We showed that pyrene accumulation and metabolization are significantly influenced by the presence of cadmium. Our results suggest that mixture effects may be dependent on exposure time.

References

Aug 1, 1996·Archives of Environmental Contamination and Toxicology·T C van Brummelen, N M van Straalen
Feb 27, 2001·Ecotoxicology and Environmental Safety·M T Fountain, S P Hopkin
Dec 31, 2002·Toxicology Letters·Soisungwan SatarugMichael R Moore
May 24, 2003·Aquatic Toxicology·Jarkko Akkanen, Jussi V K Kukkonen
Sep 16, 2004·Reviews of Environmental Contamination and Toxicology·John Jensen, Line E Sverdrup
Sep 24, 2004·Archives of Environmental Contamination and Toxicology·G J StroombergN M van Straalen
Feb 3, 2005·Environmental and Molecular Mutagenesis·William M BairdBrinda Mahadevan
Dec 6, 2005·Archives of Environmental Contamination and Toxicology·K A Gust
Jan 13, 2006·Ecotoxicology and Environmental Safety·Guoqing ShenJingbo Hong
Sep 22, 2006·Environmental Toxicology and Chemistry·Steven T J DrogeCornelis A M Van Gestel
Jun 15, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Laura GastaldiGiovanni Pons
Aug 28, 2007·International Journal of Occupational and Environmental Health·James HuffPeter F Infante
Feb 27, 2010·Ecotoxicology and Environmental Safety·Mieke Broerse, Cornelis A M van Gestel

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Citations

Aug 12, 2014·Ecotoxicology and Environmental Safety·Agnieszka J Bednarska, Justyna Kaszowska
Oct 16, 2012·Ecotoxicology and Environmental Safety·Xiaoxia YangXiufeng Cao
Nov 17, 2017·Environmental Science and Pollution Research International·Wencai DaiYongming Luo
Dec 30, 2018·Environmental Monitoring and Assessment·J GospodarekM Rusin
Jun 24, 2017·PloS One·Alex RobinsonDavid J Spurgeon
May 13, 2019·Environmental Science and Pollution Research International·Cecilia Nwadiuto AmadiOrish Ebere Orisakwe

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