Cadmium chloride induces contractions of the rat isolated urinary bladder by activation of capsaicin-sensitive sensory nerves

European Journal of Pharmacology
R PatacchiniA Meli

Abstract

Cadmium chloride (CdCl2)(30 microM-1 mM) produced a concentration-related contraction of the rat isolated urinary bladder which was abolished by tetrodotoxin (1 microM) or extrinsic bladder denervation (72 h before). Complete cross-desensitization was observed between the contractile response to Cd and capsaicin, indicating that, at the peripheral level, this inorganic calcium channel blocker can activate the 'efferent' function of capsaicin-sensitive sensory nerves.

References

Jun 1, 1986·The Journal of Pharmacy and Pharmacology·P SanticioliA Meli
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Jan 1, 1981·Annual Review of Neuroscience·S Hagiwara, L Byerly

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