PMID: 2484426Jan 1, 1989Paper

Cadmium-induced alterations in ocular trace elements. Influence of dietary selenium and copper

Biological Trace Element Research
I S Jamall, H Roque

Abstract

The present report demonstrates, for the first time, that feeding rats 50 ppm cadmium for just 7 wk results in detectable levels of cadmium in the eye of rats. Furthermore, these ocular cadmium concentrations affect significant alterations in the levels of the essential trace elements selenium, calcium, iron, and copper in the eye. Rats were fed a low-selenium (less than 0.02 ppm selenium), high-copper basal diet (50 ppm copper) supplemented with 0, 0.1, and 0.5 ppm selenium. The animals were either untreated or treated with 50 ppm cadmium admixed with their feed. Cadmium treatment resulted in significant reductions (up to 50%) in ocular selenium. Furthermore, rats fed the basal diet and given 100 ppm cadmium via their feed for 6 wk exhibited a 69% reduction in the activity of the selenoenzyme, glutathione peroxidase, in the eye. Cadmium treatment also resulted in reductions of up to 50% in ocular calcium, irrespective of dietary selenium supplementation. Iron levels were increased by 30% in rats fed the low-selenium diet and decreased by as much as 40% in rats fed the selenium-supplemented diets, compared to animals fed identical levels of selenium without cadmium. Ocular copper levels were significantly increased only in rats...Continue Reading

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Citations

Apr 25, 2009·Biological Trace Element Research·Kenya YukiKazuo Tsubota
Sep 22, 2010·Biological Trace Element Research·Hassan Imran AfridiMohammad Balal Arain
Feb 1, 1994·Cell Biology and Toxicology·M Sugiyama
May 1, 2021·International Journal of Molecular Sciences·Agnieszka KamińskaMario Damiano Toro

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