PMID: 9541642Apr 29, 1998Paper

Cadmium-induced alterations of hepatic lipid peroxidation, glutathione S-transferase activity and reduced glutathione level and their possible correlation with chromosomal aberration in mice: a time course study

Mutation Research
R KarmakarM Chatterjee

Abstract

Cadmium, a heavy metal, has been found to possess a potent toxic effect on liver and bone marrow. In the present study, attempts were made to understand whether or not any correlation existed between hepatic lipid peroxidation, glutathione S-transferase activity, reduced glutathione level and chromosome aberrations, micronucleus and mitotic index in bone marrow cells of Balb/C male mice. Cadmium chloride (2.5 mg/kg b.wt.), when administered subcutaneously for 7 alternate days, exerted duration-dependent toxic effects on hepatic biochemical and cytogenetic parameters of bone marrow. A shorter time interval (5 days) elicited no significant alteration in the case of biochemical parameters, but with the advancement of time (i.e. after 10 and 15 days) lipid peroxidation showed 102% (p < 0.001) elevation and after 15 days, glutathione S-transferase activity and reduced glutathione level decreased by 35%, (p < 0.001) and 32% (p < 0.001), respectively, from the control values with concomitant elevation of chromosomal aberrations (30%) and micronucleus (2.32%) but the mitotic index was inhibited by 1.26%. The results of our study, provided evidence of cadmium-induced duration-dependent depression of GSH-mediated GST-catalysed detoxicati...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 25, 1985·Science·P A Cerutti
Jan 1, 1972·Annual Review of Biochemistry·B L Vallee, D D Ulmer
Sep 1, 1994·Environmental Health Perspectives·A MargeliM Mykoniatis
Sep 1, 1994·Environmental Health Perspectives·A Hartwig
May 1, 1994·Toxicology and Industrial Health·W Ficek
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN

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Citations

Dec 18, 2010·Archives of Environmental Contamination and Toxicology·Catherine TsangarisKonstantin Nizheradze
Mar 22, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·U PatraA K Giri
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T FaturM Filipic
Nov 1, 1998·Environmental Toxicology and Pharmacology·R Karmakar, M Chatterjee
Jan 17, 2014·Environmental Science and Pollution Research International·Bruno NunesAlberto Teodorico Correia
Mar 9, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Sekena H Abdel-AziemMosaad A Abdel-Wahhab
May 9, 2016·Environmental Science and Pollution Research International·Azza NaïjaAhmed Noureddine Helal
Jun 10, 2008·Toxicology and Industrial Health·Meral KoyuturkSevim Tunali
Jun 11, 2020·Antioxidants·Jacopo J V BrancaMatteo Becatti
Aug 7, 2018·Frontiers in Physiology·Danli SongYongbo Bao
Sep 29, 2019·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Dirk DobritzschDirk Schaumlöffel
Jan 8, 2021·Environmental Science and Pollution Research International·Yang SuJianqing Zhu
Jun 9, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Itzayana Pérez-AlvarezGermán Chamorro-Cevallos

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