Cadmium induced endothelial dysfunction: consequence of defective migratory pattern of endothelial cells in association with poor nitric oxide availability under cadmium challenge

Cell Biology International
Gopi Krishna KolluruSuvro Chatterjee

Abstract

Recent advances in cadmium toxicity research suggest an association between cadmium and vascular diseases. However, the mechanisms of cadmium implications in vascular diseases are not yet explained. The objective of our present study is to explore the mechanism of cadmium induced endothelial dysfunction. Doses of 0, 1 and 5microM cadmium chloride were used to test the effects of cadmium on nitric oxide induced tube formation, cellular migration and subcellular actin polymerization in ECV-304 endothelial cells. An egg-yolk vascular bed model was used to study the effects of cadmium on angiogenesis. Results of the present study show that 5microM cadmium chloride effectively inhibited angiogenesis, cellular migration and tube formation. Phalloidin staining, which represents actin polymerization of endothelial cells, reveals that cadmium induces an altered F-actin pattern, which could be the prime cause for cadmium mediated inhibition of cellular migration and angiogenesis. Cadmium was also found to inhibit nitric oxide production in endothelial cells in a calcium free medium, which further hints that cadmium might impair endothelial functions by inhibiting endothelial nitric oxide synthase.

Citations

Oct 20, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Walter C ProzialeckWilliam D Atchison
Sep 16, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chang Seok ParkYoung Ho Koh
Oct 11, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yi JingBing-Hua Jiang
Mar 28, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Syamantak MajumderSuvro Chatterjee
Sep 22, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Syamantak MajumderSuvro Chatterjee
Aug 7, 2012·Journal of Cell Communication and Signaling·Jagna Chmielowska-Bąk, Joanna Deckert
Dec 6, 2011·Bulletin of Environmental Contamination and Toxicology·M SavabieasfahaniS Goodarzi
Dec 22, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Hamed Kolangi MiandareRoghieh Safari
Jan 18, 2011·Toxicology and Applied Pharmacology·Ana Maria RoncoMiguel N Llanos
Aug 31, 2010·European Journal of Cell Biology·Swaraj SinhaSuvro Chatterjee
Feb 18, 2014·Journal of Proteome Research·John M PrinsYinsheng Wang
Jul 1, 2009·Environmental Toxicology and Pharmacology·Sohail EjazChae Woong Lim
Dec 9, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zhiwu DongJunying Miao
Sep 15, 2015·Toxicology and Applied Pharmacology·Anna Kaskova GheorghescuJennifer Thompson
Feb 14, 2013·Cell Biology International·Shunmugam NagarajanSuvro Chatterjee
Oct 4, 2014·Acta Veterinaria Scandinavica·Hana DuranovaRobert Toman
Nov 22, 2015·Cellular and Molecular Life Sciences : CMLS·Barbara MessnerDavid Bernhard
Feb 5, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J M WoodsW C Prozialeck
Mar 15, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Adrian TürkcanBarbara Messner
Mar 3, 2015·Animal Reproduction Science·E MarettováJ Legáth
Dec 11, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vimal VeeriahSuvro Chatterjee
Sep 17, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Eric M HechtCharles H Hennekens
Sep 8, 2015·International Journal of Environmental Research and Public Health·Fuhong LiuJu Liu
Sep 6, 2017·International Journal of Molecular Sciences·Qiuan ZhongXue Pan
Apr 8, 2017·Oncotarget·Tianshu WeiJu Liu
Aug 21, 2019·Journal of the American Heart Association·Tiange LiuNoel T Mueller
Mar 4, 2020·Environmental Science and Pollution Research International·Hamda A Al-Naemi, Sandra Concepcion Das
Apr 16, 2020·Current Pharmaceutical Design·Camila Cruz Pereira AlmenaraAlessandra S Padilha
Jan 28, 2021·Journal of Endocrinological Investigation·V M BimonteS Migliaccio
Jan 22, 2021·Current Hypertension Reviews·Airton C MartinsMonica M B Paoliello

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