Cadmium-induced lipid peroxidation and the antioxidant system in rat erythrocytes: the role of antioxidants

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
S SarkarD Bhatnagar

Abstract

Cadmium (Cd)-induced oxidative damage in erythrocytes causes loss of membrane function by enhancing lipid peroxidation (LPO) and altering the erythrocyte antioxidant system. Vitamin E and/or selenium (Se) was administered to rats, prior to Cd intoxication, in order to prepare the animals to withstand oxidative assault. The treatment with Cd increased LPO in erythrocytes while animals pretreated with vitamin E and/or Se prior to Cd treatment showed decreased LPO as compared with animals given Cd alone. The erythrocyte SOD and CAT activities decreased significantly with Cd treatment. The pretreatment with vitamin E and/or Se prior to Cd administration partially reversed such changes. The erythrocytes showed a marked depletion in glutathione (GSH) content with Cd treatment. The antioxidant treatments before Cd administration helped to maintain the erythrocyte GSH content. The erythrocyte glutathione reductase (GSH-R) activity increased markedly when treatments with vitamin E and Se were applied. The GSH-R activity was not observed to decrease in animals treated with antioxidant prior to Cd intoxication, which may mean that the replenishment of erythrocyte GSH content is via GSH-R. The glutathione-S-transferase (GST) activity incre...Continue Reading

References

Feb 15, 1984·Experientia·J C Sherlock

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Citations

Nov 21, 2007·European Journal of Nutrition·Delphine GitenayEdmond Rock
Sep 18, 2007·Biological Trace Element Research·Vahit KonarFikret Karatas
Sep 18, 2007·Biological Trace Element Research·Nadir Rencuzogullari, Suat Erdogan
Sep 11, 2008·Biological Trace Element Research·Fikret KaratasSinan Saydam
Sep 17, 2009·Biological Trace Element Research·Fikret KaratasHaki Kara
Feb 22, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Athanasios C PappasKonstantinos Fegeros
Jun 20, 2007·Nihon eiseigaku zasshi. Japanese journal of hygiene·Hyogo Horiguchi
Apr 10, 2008·Journal of Clinical Biochemistry and Nutrition·Manisha ModakThomas Paul A Devasagayam
Feb 28, 2014·Biological Trace Element Research·Li-Li LiuShi-Wen Xu
Feb 14, 2009·Biological Trace Element Research·Imed MessaoudiAbdelhamid Kerkeni
Jun 4, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Stephen M Suru
Sep 26, 2009·Toxicology Mechanisms and Methods·Ikbal M OzturkSemra Erdogan
Feb 13, 2016·Neurochemical Research·Ziyan ZhangMichael Aschner
May 26, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Imed MessaoudiAbdelhamid Kerkeni
Mar 6, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Danijela Djukić-CosićVesna Matović
Nov 6, 2007·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Hedya JemaiAbdelhamid Kerkeni
Oct 12, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Neelam Yadav, Shashi Khandelwal
Apr 24, 2007·Toxicology·A S El-SharakyS A Sheweita
Dec 25, 2010·Environmental Toxicology and Chemistry·Suyoung KimKyungho Choi
Aug 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fatma M El-DemerdashHoda H Baghdadi
Aug 21, 2013·Saudi Journal of Biological Sciences·Amal I El-Refaiy, Fawzy I Eissa
Jun 4, 2013·Pathophysiology : the Official Journal of the International Society for Pathophysiology·S F Ige, R E Akhigbe
Jun 9, 2016·International Journal of Immunopathology and Pharmacology·Adel El-Sayed El-TarrasAdnan Abelghani Amin
Jul 13, 2007·Journal of Applied Toxicology : JAT·Ana P ArdaisCristina W Nogueira
Jun 13, 2008·Journal of Applied Toxicology : JAT·Mahua SinhaParames C Sil
Aug 8, 2018·FEMS Microbiology Letters·Zhiwei HuangPing Shi
Sep 24, 2010·Arhiv za higijenu rada i toksikologiju·Maja Lazarus
Feb 24, 2001·Archives of Biochemistry and Biophysics·E CasalinoC Landriscina
Sep 3, 2002·Toxicology·Elisabetta CasalinoClemente Landriscina
Oct 16, 2009·Ecotoxicology and Environmental Safety·Shu-Feng HuangFang-Fang Hu

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