Cadmium-induced olfactory dysfunction in rainbow trout: Effects of binary and quaternary metal mixtures

Aquatic Toxicology
William A DewGreg G Pyle

Abstract

A functioning olfactory response is essential for fish to be able to undertake essential behaviors. The majority of work investigating the effects of metals on the olfactory response of fish has focused on single-metal exposures. In this study we exposed rainbow trout to cadmium, copper, nickel, zinc, or a mixture of these four metals at or below the current Canadian Council of Ministers of the Environment guidelines for the protection of aquatic life. Measurement of olfactory acuity using an electro-olfactogram demonstrated that cadmium causes significant impairment of the entire olfactory system, while the other three metals or the mixture of all four metals did not. Binary mixtures with cadmium and each of the other metals demonstrated that nickel and zinc, but not copper, protect against cadmium-induced olfactory dysfunction. Testing was done to determine if the protection from cadmium-induced olfactory dysfunction could be explained by binding competition between cadmium and the other metals at the cell surface, or if the protection could be explained by an up-regulation of an intracellular detoxification pathway, namely metallothionein. This study is the first to measure the effects of binary and quaternary metal mixtures...Continue Reading

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Citations

Oct 10, 2018·Environmental Toxicology and Chemistry·Jeffrey M MorrisJoshua Lipton
Dec 12, 2018·Ecotoxicology and Environmental Safety·Ebrahim LariGreg G Pyle
May 30, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Hui LiXianghui Kong
Jun 5, 2021·Integrative and Comparative Biology·Piyumika S SuriyampolaEmília P Martins
Aug 17, 2021·Environmental Science & Technology·Sarah KönemannColette Vom Berg

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