Cadmium, mercury, and lead in kidney cortex of living kidney donors: Impact of different exposure sources

Environmental Research
L BarregårdGerd Sallsten

Abstract

Most current knowledge on kidney concentrations of nephrotoxic metals like cadmium (Cd), mercury (Hg), or lead (Pb) comes from autopsy studies. Assessment of metal concentrations in kidney biopsies from living subjects can be combined with information about exposure sources like smoking, diet, and occupation supplied by the biopsied subjects themselves. To determine kidney concentrations of Cd, Hg, and Pb in living kidney donors, and assess associations with common exposure sources and background factors. Metal concentrations were determined in 109 living kidney donors aged 24-70 years (median 51), using inductively coupled plasma-mass spectrometry (Cd and Pb) and cold vapor atomic fluorescence spectrometry (Hg). Smoking habits, occupation, dental amalgam, fish consumption, and iron stores were evaluated. The median kidney concentrations were 12.9microg/g (wet weight) for cadmium, 0.21microg/g for mercury, and 0.08microg/g for lead. Kidney Cd increased by 3.9microg/g for a 10 year increase in age, and by 3.7microg/g for an extra 10 pack-years of smoking. Levels in non-smokers were similar to those found in the 1970s. Low iron stores (low serum ferritin) in women increased kidney Cd by 4.5microg/g. Kidney Hg increased by 6% for ...Continue Reading

References

Jan 1, 1990·Biology of Metals·C G ElinderB Palm
Jan 1, 1987·International Archives of Occupational and Environmental Health·R HahnH W Schlipköter
Apr 1, 1986·The Science of the Total Environment·L GerhardssonP O Wester
Aug 18, 1995·The Science of the Total Environment·M TorraJ Corbella
Feb 1, 1995·Occupational and Environmental Medicine·L BarregårdB Järvholm
Jan 1, 1996·Journal of Dental Research·G SällstenG Skarping
Dec 1, 1996·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·G DraschS Strobach
May 20, 1998·Scandinavian Journal of Clinical and Laboratory Investigation·G Sandborgh-EnglundC Valtersson
Aug 4, 1998·Human & Experimental Toxicology·C OrlowskiA Gross
Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Sep 13, 2000·Occupational and Environmental Medicine·L JärupC G Elinder
Dec 5, 2000·Scandinavian Journal of Work, Environment & Health·D G EllingsenY Thomassen
Sep 1, 2001·Journal of Environmental Monitoring : JEM·T D LyonG S Fell
Oct 23, 2001·Journal of Occupational and Environmental Medicine·X WuG Nordberg
Mar 21, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lars Järup
Jul 16, 2002·Environmental Health Perspectives·Tobias AlfvénCarl-Gustaf Elinder
May 6, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tobias AlfvénLars Järup
May 20, 2005·Occupational and Environmental Medicine·L Barregard
Oct 14, 2005·Environmental Research·Maria WennbergStaffan Skerfving
Sep 15, 2006·The Science of the Total Environment·Poul JohansenFrank Riget
Oct 26, 2006·Kidney International·E B EkongV M Weaver
Mar 21, 2007·The Science of the Total Environment·Poul JohansenFrank Riget

❮ Previous
Next ❯

Citations

Jun 10, 2011·International Archives of Occupational and Environmental Health·Magnus AkerstromGerd Sallsten
Oct 3, 1992·Lancet·J S NajarianA J Matas
Dec 7, 2011·International Journal of Dentistry·Yurdanur Uçar, William A Brantley
Mar 19, 2013·Environmental Health : a Global Access Science Source·Maria WallinLars Barregard
Jan 25, 2013·Environmental Health : a Global Access Science Source·Johan Nilsson SommarIngvar A Bergdahl
Mar 29, 2013·International Archives of Occupational and Environmental Health·Mohammad Bakhtiar HossainKarin Broberg
Apr 15, 2014·Biological Trace Element Research·Montse MariJosé L Domingo
Feb 6, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Yael BarJohan Mölne
Mar 19, 2013·The Science of the Total Environment·Rim KhlifiAmel Hamza-Chaffai
Mar 5, 2013·Toxicology and Applied Pharmacology·Magnus AkerstromGerd Sallsten
Jul 26, 2011·The Science of the Total Environment·G M RichardsonJ Gravière
May 25, 2010·Toxicology Letters·Yasushi SuwazonoAgneta Akesson
Apr 3, 2016·American Journal of Epidemiology·Scott V AdamsPolly A Newcomb
May 20, 2014·Environmental Research·Piotr RzymskiTomasz Opala
Mar 30, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Helena BjermoPer Ola Darnerud
Oct 8, 2014·Occupational and Environmental Medicine·Maria WallinLars Barregard
Aug 4, 2016·Environmental Geochemistry and Health·Aleksandra WilkNatalia Łanocha-Arendarczyk
Jul 13, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin Niclas FranssonGunnar Johanson
Jul 29, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Emese AsztalosMassimo Trotta
Mar 30, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Koustav GangulyAnders Lindén
Mar 10, 2017·Biological Trace Element Research·Aleksandra WilkElżbieta Kalisińska
Jan 31, 2017·The Tohoku Journal of Experimental Medicine·Soisungwan SatarugGlenda C Gobe
Mar 15, 2018·Toxics·Soisungwan Satarug
Feb 22, 2017·Biological Trace Element Research·Teresa Lech, Józefa K Sadlik
Oct 18, 2020·Toxics·Soisungwan SatarugKenneth R Phelps
Jan 8, 2021·Biological Trace Element Research·S A GunawardenaJ W Gunawardana
Jun 6, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Sameera A GunawardenaSaroj Jayasinghe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.