Cadmium suppresses delta 9 desaturase activity in rat hepatocytes

Toxicology
N Kudo, K Waku

Abstract

The effects of cadmium (Cd) on the fatty acid composition and delta 9 desaturation activity were studied in hepatocytes which had been cultured in serum-free medium. The aim of this study was to determine whether the inhibition of delta 9 desaturase seen in Cd-treated rat liver (Kudo et al. (1991) Toxicology, 68, 133-142) is the direct effect of Cd or not. When hepatocytes were cultured in serum-free medium, increases in the proportions of monounsaturated fatty acids such as oleic acid (18:1) were observed in the phospholipid (PL) and triacylglycerol (TG) fractions of hepatocytes, suggesting that delta 9 desaturase was induced. By contrast, essential fatty acids such as linoleic acid (18:2) and arachidonic acid (20:4) decreased. These changes were similar to those seen in the livers of essential fatty acid (EFA)-deficient rats. When hepatocytes were cultured in the presence of CdCl2, the changes in the fatty acid composition were suppressed. The effect of CdCl2 was concentration-dependent. The rate of the conversion of 18:0 to 18:1, which is catalyzed by delta 9 desaturase, was reduced by treatment with Cd, whereas the rate of conversion of 18:2 to 20:4, which is catalyzed by delta 6 desaturase, was slightly increased. Cd did n...Continue Reading

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Citations

Jun 25, 2013·Biological Trace Element Research·Natalia N FokinaIgor N Bakhmet
Mar 17, 2004·Toxicology Letters·Kierstin Petersson GrawéAgneta Oskarsson
Feb 15, 2002·Toxicology·Dario C Ramirez, María S Gimenez
Oct 27, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Silvina Mónica AlvarezMaría Sofía Giménez
Oct 24, 2007·Toxicology·A A NewairyS A Sheweita
Apr 24, 2007·Toxicology·A S El-SharakyS A Sheweita
Mar 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ethel V LarregleMaría S Giménez
Jul 28, 2016·The Science of the Total Environment·Ambrogina AlbergamoLuigi Mondello
Nov 19, 2019·Environmental Toxicology·Peng ShiXiaojun Yan
Jun 11, 2017·Biological Trace Element Research·Tomasz OlszowskiDariusz Chlubek

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