PMID: 3754681Feb 1, 1986Paper

Cadmium toxicity in kidney cells. Resistance induced by short term pretreatment in vitro and in vivo

Acta Pharmacologica Et Toxicologica
Taiyi Jin, G F Nordberg

Abstract

Epithelial cells from the kidney were freshly isolated from rats pretreated by daily subcutaneous doses of CdCl2 in vivo (0.5-2 mg Cd/kg X 5). Such cells were incubated in vitro in media with different concentrations of cadmium chloride (0-200 micrograms Cd/ml). There was no inhibition of cell growth in such cells. However, in cells isolated from non-treated rats, in vitro exposure to the same concentrations of CdCl2 caused a dose dependent decrease in viability. When cells, isolated from non-treated rats were pretreated in vitro with CdCl2 (10 micrograms/ml) and subsequently exposed to cadmium chloride (0-200 micrograms/ml), a protective effect was observed, which was similar to the one observed in cells isolated from animals pretreated with CdCl2. The concentration of metallothionein in the cells treated with cadmium was increased. A lower uptake of cadmium chloride, in vitro has been observed in kidney cells pretreated in vivo or in vitro compared to nonpretreated cells. Subcellular distribution studies indicate that Cd-distribution was similar in pretreated and non-pretreated cells, but concentrations were generally lower in the pretreated cells. The decreased uptake of Cd by pretreated kidney cells is a sign of Cd-interfer...Continue Reading

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Citations

Jan 1, 1989·Critical Reviews in Toxicology·O Andersen
Jul 10, 2007·International Journal of Environmental Research and Public Health·Jorge Herkovits, Cristina Silvia Pérez-Coll
Jul 1, 1989·Biological Trace Element Research·G F Nordberg
Dec 18, 2001·Microscopy Research and Technique·R Swiergosz-Kowalewska
Sep 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·D J Hazen-MartinM A Sens
Jan 1, 1990·Cell Biology and Toxicology·S R CloughM J Brabec
Dec 1, 1986·Journal of Applied Toxicology : JAT·T JinM Nordberg
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A J Gandolfi, K Brendel

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