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CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features

Frontiers in Genetics

Feb 19, 2019

Vinay K KarthaStefano Monti

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Abstract

The identification of genetic alteration combinations as drivers of a given phenotypic outcome, such as drug sensitivity, gene or protein expression, and pathway activity, is a challenging task that is essential to gaining new biological insights and to discovering therapeutic targets. ...read more

Mentioned in this Paper

Pharmacotherapy
Genes
Genome
Oncogenes
deoxy(thymidylyl-cytidylyl-guanylyl-adenylic acid)
Protein S
Cell Line, Tumor
Diagnostic Procedures on Testes
Tumor Cells, Malignant
Somatic Mutation
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  • CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features

    Frontiers in Genetics

    Feb 19, 2019

    Vinay K KarthaStefano Monti

    PMID: 30838036

    DOI: 10.3389/fgene.2019.00121

    Abstract

    The identification of genetic alteration combinations as drivers of a given phenotypic outcome, such as drug sensitivity, gene or protein expression, and pathway activity, is a challenging task that is essential to gaining new biological insights and to discovering therapeutic targets. ...read more

    Mentioned in this Paper

    Pharmacotherapy
    Genes
    Genome
    Oncogenes
    deoxy(thymidylyl-cytidylyl-guanylyl-adenylic acid)

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