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CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features

Frontiers in Genetics

Mar 7, 2019

Vinay K KarthaStefano Monti

Abstract

The identification of genetic alteration combinations as drivers of a given phenotypic outcome, such as drug sensitivity, gene or protein expression, and pathway activity, is a challenging task that is essential to gaining new biological insights and to discovering therapeutic targets. ...read more

Mentioned in this Paper

The Cancer Genome Atlas
Genome
Genes
Somatic Mutation
Genomics
Pharmacologic Substance
Protein S
Tumor Cells, Malignant
Genomic DNA
Pharmacotherapy
2
2
8
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CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features

Frontiers in Genetics

Mar 7, 2019

Vinay K KarthaStefano Monti

PMID: 30838036

DOI: 10.3389/fgene.2019.00121

Abstract

The identification of genetic alteration combinations as drivers of a given phenotypic outcome, such as drug sensitivity, gene or protein expression, and pathway activity, is a challenging task that is essential to gaining new biological insights and to discovering therapeutic targets. ...read more

Mentioned in this Paper

The Cancer Genome Atlas
Genome
Genes
Somatic Mutation
Genomics
Pharmacologic Substance
Protein S
Tumor Cells, Malignant
Genomic DNA
Pharmacotherapy
2
2
8

Similar Papers Found In These Feeds

Drug & Digital Interventions

This feed describes how digital interventions, which are digital and mobile technologies used to support health system needs, can complement and improve pharmacotherapy in disease management. Discover the latest research on drug and digtial intervention here,

Hippo Pathway-YAP/TAZ

The Hippo pathway regulates diverse cellular phenotypes such as organ size, angiogenesis, tissue regeneration and self-renewal. YAP and TAZ important transcriptional coactivators downstream of hippo signaling. Discover the latest research on Hippo Pathway-YAP/TAZ here.

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