Caenorhabditis elegans immune conditioning with the probiotic bacterium Lactobacillus acidophilus strain NCFM enhances gram-positive immune responses.

Infection and Immunity
Younghoon Kim, Eleftherios Mylonakis

Abstract

Although the immune response of Caenorhabditis elegans to microbial infections is well established, very little is known about the effects of health-promoting probiotic bacteria on evolutionarily conserved C. elegans host responses. We found that the probiotic Gram-positive bacterium Lactobacillus acidophilus NCFM is not harmful to C. elegans and that L. acidophilus NCFM is unable to colonize the C. elegans intestine. Conditioning with L. acidophilus NCFM significantly decreased the burden of a subsequent Enterococcus faecalis infection in the nematode intestine and prolonged the survival of nematodes exposed to pathogenic strains of E. faecalis and Staphylococcus aureus, including multidrug-resistant (MDR) isolates. Preexposure of nematodes to Bacillus subtilis did not provide any beneficial effects. Importantly, L. acidophilus NCFM activates key immune signaling pathways involved in C. elegans defenses against Gram-positive bacteria, including the p38 mitogen-activated protein kinase pathway (via TIR-1 and PMK-1) and the β-catenin signaling pathway (via BAR-1). Interestingly, conditioning with L. acidophilus NCFM had a minimal effect on Gram-negative infection with Pseudomonas aeruginosa or Salmonella enterica serovar Typhimu...Continue Reading

References

Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·M W TanF M Ausubel
Jan 29, 2000·Immunology and Cell Biology·T Matsuzaki, J Chin
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A GarsinF M Ausubel
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 5, 2002·Lancet·Tadashi BabaKeiichi Hiramatsu
Jul 27, 2002·Science·Dennis H KimFrederick M Ausubel
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nicole T LiberatiFrederick M Ausubel
Jan 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eric AltermannTodd R Klaenhammer
Mar 2, 2005·Trends in Microbiology·Costi D SifriFrederick M Ausubel
Jan 1, 1991·Applied and Environmental Microbiology·K DoneganA Porteous
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Terence I MoyFrederick M Ausubel
Feb 6, 2007·PLoS Pathogens·Julia BregerEleftherios Mylonakis
May 22, 2007·BMC Microbiology·Jintae LeeThomas K Wood
Nov 3, 2007·EMBO Reports·Jennifer L Tenor, Alejandro Aballay
Mar 18, 2008·Nature Reviews. Microbiology·Jerry M Wells, Annick Mercenier
Nov 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Javier E IrazoquiFrederick M Ausubel
Dec 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sergey R KonstantinovYvette van Kooyk
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jennifer R PowellFrederick M Ausubel
Dec 24, 2009·Nature Reviews. Immunology·Javier E IrazoquiFrederick M Ausubel
Feb 17, 2010·Nature Reviews. Microbiology·Sarah LebeerSigrid C J De Keersmaecker
Jul 31, 2010·Gut Microbes·Carissa M Thomas, James Versalovic
Sep 11, 2010·Biochemical and Biophysical Research Communications·Xiangming WangDanqiao Wang
Nov 30, 2010·Nature Reviews. Microbiology·Gregor ReidHenk J Busscher
Jan 12, 2011·Journal of Food Protection·Chunyang WangParviz M Sabour
Mar 1, 2011·Mechanisms of Ageing and Development·Shuhei SoYasumi Ohshima
Jul 7, 2011·PLoS Pathogens·Read Pukkila-WorleyEleftherios Mylonakis

❮ Previous
Next ❯

Citations

Jan 16, 2013·Applied Microbiology and Biotechnology·Jin-Hyung LeeJintae Lee
Jan 8, 2013·Biogerontology·Tomomi KomuraYoshikazu Nishikawa
Dec 12, 2012·Infection and Immunity·Sirena Montalvo-KatzMichael Shapira
Aug 6, 2013·EMBO Molecular Medicine·Filipe Cabreiro, David Gems
Sep 3, 2013·Current Opinion in Pharmacology·Marios ArvanitisEleftherios Mylonakis
Oct 31, 2013·Cellular Microbiology·Laura C Clark, Jonathan Hodgkin
Feb 6, 2015·Virulence·Gerwald Köhler
May 12, 2015·BioMed Research International·Elena ZanniChiara Devirgiliis
May 11, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Katja DierkingHinrich Schulenburg
Jul 13, 2016·Seminars in Immunology·Barbara Milutinović, Joachim Kurtz
Apr 21, 2018·Molecular Plant Pathology·Young Cheol Kim, Anne J Anderson
Jun 29, 2014·Applied and Environmental Microbiology·S Anaid Diaz, Olivier Restif
Feb 13, 2016·Nutrition Research and Practice·Seul-Ki ParkOk Sarah Shin
Nov 28, 2018·Korean Journal for Food Science of Animal Resources·Jaeyoung HeoSangnam Oh
Oct 30, 2019·International Journal of Molecular Sciences·Marianna RoselliChiara Devirgiliis
Oct 5, 2019·Cellular and Molecular Life Sciences : CMLS·Arun KumarMojibur Khan
Mar 19, 2019·Food Science of Animal Resources·Kyoung Hee YangYoung Jun Kim
Mar 1, 2019·Life·Daniel Rodríguez Amor, Martina Dal Bello
Aug 17, 2019·Nature Reviews. Microbiology·Angela E Douglas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.