Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8

Genetics
David GarbeMeera V Sundaram

Abstract

Retinoblastoma (Rb)/E2F complexes repress expression of many genes important for G(1)-to-S transition, but also appear to regulate gene expression at other stages of the cell cycle. In C. elegans, lin-35/Rb and other synthetic Multivulva (SynMuv) group B genes function redundantly with other sets of genes to regulate G(1)/S progression, vulval and pharyngeal differentiation, and other unknown processes required for viability. Here we show that lin-35/Rb, efl-1/E2F, and other SynMuv B genes negatively regulate a component of the anaphase-promoting complex or cyclosome (APC/C). The APC/C is a multisubunit complex that promotes metaphase-to-anaphase progression and G(1) arrest by targeting different substrates for ubiquitination and proteasome-mediated destruction. The C. elegans APC/C gene mat-3/APC8 has been defined by temperature-sensitive embryonic lethal alleles that strongly affect germline meiosis and mitosis but only weakly affect somatic development. We describe severe nonconditional mat-3 alleles and a hypomorphic viable allele (ku233), all of which affect postembryonic cell divisions including those of the vulval lineage. The ku233 lesion is located outside of the mat-3 coding region and reduces mat-3 mRNA expression. L...Continue Reading

References

Mar 1, 1977·Developmental Biology·J E Sulston, H R Horvitz
May 1, 1974·Genetics·S Brenner
Aug 1, 1980·Developmental Biology·J E Sulston, J G White
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·A SchulzeB Henglein
Apr 1, 1994·Molecular Biology of the Cell·L S HuangP W Sternberg
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·K OhtaniJ R Nevins
Oct 6, 2000·Genes & Development·J W Harbour, D C Dean
Jan 3, 2001·The Journal of Cell Biology·A GoldenD C Shakes
Mar 10, 2001·Current Topics in Developmental Biology·M Wang, P W Sternberg
Oct 5, 2001·Molecular Cell·A DahiyaD C Dean
Jan 19, 2002·Genes & Development·Bing RenBrian David Dynlacht
Jun 7, 2002·Molecular Cell·Jan-Michael Peters
Jun 14, 2002·Current Biology : CB·Mike Boxem, Sander van den Heuvel
Sep 5, 2002·Genes & Development·J Wade HarperMark J Solomon
Dec 11, 2002·Current Opinion in Cell Biology·Olivier Stevaux, Nicholas J Dyson
Jan 10, 2003·Nucleic Acids Research·V MatysE Wingender
Aug 28, 2003·Médecine sciences : M/S·Christelle Gally, Jean-Louis Bessereau
Sep 17, 2003·Genes & Development·Dessislava K DimovaNicholas J Dyson

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Citations

Apr 20, 2005·Oncogene·Desssislava K Dimova, Nicholas J Dyson
Nov 1, 2016·Nature Reviews. Genetics·Benjamin E HousdenNorbert Perrimon
Dec 11, 2021·Frontiers in Plant Science·Rodrigo Porto SchwederskyPaulo Cavalcanti Gomes Ferreira

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