Caenorhabditis elegans nuclear receptors: insights into life traits.

Trends in Endocrinology and Metabolism : TEM
Daniel B Magner, Adam Antebi

Abstract

Nuclear receptors are a class of hormone-gated transcription factors found in metazoans that regulate global changes in gene expression when bound to their cognate ligands. Despite species diversification, nuclear receptors function similarly across taxa, having fundamental roles in detecting intrinsic and environmental signals, and subsequently in coordinating transcriptional cascades that direct reproduction, development, metabolism and homeostasis. These endocrine receptors function in vivo in part as molecular switches and timers that regulate transcriptional cascades. Several Caenorhabditis elegans nuclear receptors integrate intrinsic and extrinsic signals to regulate the dauer diapause and longevity, molting, and heterochronic circuits of development, and are comparable to similar in vivo endocrine regulated processes in other animals.

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Citations

Apr 19, 2011·Annual Review of Biochemistry·Joshua Wollam, Adam Antebi
Sep 13, 2011·The Journal of Biological Chemistry·Noelia NunezMerlin Crossley
Oct 18, 2012·Annual Review of Entomology·Ronald J HillMichael C Lawrence
Mar 18, 2009·The Journal of Physiology·Clark J NelsonHannah V Carey
Sep 22, 2010·Experimental Gerontology·Martina GálikováThomas Flatt
May 13, 2010·Gene Expression Patterns : GEP·Jaroslav VohankaMarta Kostrouchová
Aug 27, 2010·Annals of the New York Academy of Sciences·Marc Tatar
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Jan 16, 2018·Nuclear Receptor Research·Shari BodofskyBruce Wightman
Sep 9, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Min-Chul LeeJae-Seong Lee

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