Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

Nature
G J BeitelH R Horvitz

Abstract

The let-60 gene, an essential ras gene of the nematode Caenorhabditis elegans, acts as a switch in the inductive signalling pathway that initiates vulva formation. Recessive let-60 mutations that cause a vulvaless phenotype prevent let-60 function in response to the inductive signal. These mutations are clustered and define regions necessary either for the activation or for the action of the let-60 ras protein. Dominant let-60 mutations that cause a multivulva phenotype alter codon 13 and activate let-60 in vivo, rendering it independent of the inductive signal. The let-60 gene acts within an extensively defined genetic pathway, and other genes within this pathway seem likely to encode molecules that regulate let-60 function as well as molecules that are targets of let-60 action.

References

Mar 1, 1977·Developmental Biology·J E Sulston, H R Horvitz
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J DownwardR A Weinberg
Apr 6, 1990·Science·A Wolfman, I G Macara
Aug 23, 1990·Nature·J DownwardD A Cantrell
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I S SigalE M Scolnick
Jun 1, 1988·Trends in Neurosciences·P W Sternberg
Jul 1, 1986·Molecular and Cellular Biology·B M WillumsenD R Lowy
Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
Mar 14, 1986·Cell·P W Sternberg, H R Horvitz
Sep 5, 1973·Journal of Molecular Biology·L Prakash, F Sherman
May 1, 1974·Genetics·S Brenner
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S L BoltenR H Waterston
Jan 22, 1982·Nucleic Acids Research·S M Mount
Aug 1, 1980·Developmental Biology·J E Sulston, J G White
Feb 1, 1981·Mutation Research·D G Moerman, D L Baillie

❮ Previous
Next ❯

Citations

Jul 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Golden, P W Sternberg
May 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L M Selfors, M J Stern
Jun 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Sundaram, M Han
Dec 1, 1995·Molecular Reproduction and Development·P W SternbergG Jongeward
May 1, 1997·Developmental Biology·T Lee, D J Montell
Mar 15, 2005·Molecular Genetics and Genomics : MGG·John YochemRobert K Herman
Jan 1, 1994·Progress in Biophysics and Molecular Biology·B Margolis
Dec 10, 1991·Biochimica Et Biophysica Acta·H Haubruck, F McCormick
Mar 1, 1994·Cellular Signalling·L Wiesmüller, F Wittinghofer
Oct 1, 1994·Mechanisms of Development·J CasanovaG Struhl
Dec 1, 1994·Trends in Cell Biology·C Wilson
Mar 31, 2004·Experimental Cell Research·Madhavi AgarwalDenis A Larochelle
Jun 19, 1998·Biochimica Et Biophysica Acta·R A AspburyH H Rees
Mar 22, 2003·Experimental Cell Research·Nadeem Moghal, Paul W Sternberg
Nov 24, 1998·Trends in Genetics : TIG·P W Sternberg, M Han
Nov 6, 2002·Biochimica Et Biophysica Acta·Dorota A Bulik, Phillips W Robbins
Jul 12, 2013·Nature Reviews. Cancer·Subhashini Sadasivam, James A DeCaprio
Oct 10, 2006·Oncogene·G Jannot, M J Simard
Jun 10, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·S HayashizakiM Yamamoto
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·B B Riley, D J Grunwald
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·W SwatF W Alt
Apr 1, 1994·Molecular Biology of the Cell·L S HuangP W Sternberg
May 1, 1997·Molecular Biology of the Cell·G M Lesa, P W Sternberg
Jul 25, 2007·Bioinformatics·Xiaoyun Sun, Pengyu Hong

❮ Previous
Next ❯

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