Caerin1.1 Suppresses the Growth of Porcine Epidemic Diarrhea Virus In Vitro via Direct Binding to the Virus

Viruses
Nan GuoQigai He

Abstract

Porcine epidemic diarrhea (PED) has re-emerged in recent years and has already caused huge economic losses to the porcine industry all over the world. Therefore, it is urgent for us to find out efficient ways to prevent and control this disease. In this study, the antiviral activity of a cationic amphibian antimicrobial peptide Caerin1.1 against porcine epidemic diarrhea virus (PEDV) was evaluated by an in vitro system using Vero cells. We found that even at a very low concentration, Caerin1.1 has the ability to destroy the integrity of the virus particles to block the release of the viruses, resulting in a considerable decrease in PEDV infections. In addition, Caerin1.1 showed powerful antiviral activity without interfering with the binding progress between PEDV and the receptor of the cells, therefore, it could be used as a potential antiviral drug or as a microbicide compound for prevention and control of PEDV.

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Citations

Feb 10, 2019·Inflammopharmacology·Muhammad DaniyalWei Wang
Nov 18, 2020·Antibiotics·Guihong PenJianhua Wang
Mar 8, 2021·Peptides·Hamid HeydariMehrdad Moosazadeh Moghaddam
Oct 5, 2021·Journal of Applied Microbiology·Mine Erdem Büyükkiraz, Zülal Kesmen

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Methods Mentioned

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electrophoresis
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Software Mentioned

Image J
Graph Pad Prism5

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