Abstract
Hypotensive states that require fast stabilisation of blood pressure can occur during anaesthesia. In 1963, the 20:1 mixture of cafedrine/theodrenaline (Akrinor) was introduced in Germany for use in anaesthesia and emergency medicine in the first-line management of hypotensive states. Though on the market for many years, few pharmacodynamic data are available on this combination net beta-mimetic agent. This study aimed to examine the drug combination in real-life clinical practice and recorded time to 10 % mean arterial blood pressure (MAP) increase and heart rate. Furthermore, potential factors that influence drug effectiveness under anaesthesia were assessed. Data were collected within a standardised anaesthesia protocol. A total of 353 consecutive patients (female/male = 149/204) who received cafedrine/theodrenaline after a drop in MAP ≥ 5% were included in the study. The time to 10 % increase in MAP, dosage of cafedrine/theodrenaline, volume loading, blood pressure and heart rate were monitored over time. Patients were a mean (standard deviation) of 64.4 ± 15.1 years old with a baseline MAP of 82 ± 14 mmHg, which dropped to a mean of 63 ± 10 mmHg during anaesthesia without gender differences. Cafedrine/theodrenaline (1.27 ±...Continue Reading
References
Dec 1, 1986·Circulation·M B FowlerM R Bristow
Jun 1, 1969·Japanese Journal of Pharmacology·K SakaiK Hashimoto
May 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P Morgan
May 29, 1998·British Journal of Anaesthesia·D J BuggyG T O'Brien
Nov 10, 1998·Anaesthesia and Intensive Care·J C YapJ L Derrick
Jan 11, 2001·Der Anaesthesist·A R HellerD M Albrecht
May 29, 2002·Anesthesia and Analgesia·Bernd HartmannGunter Hempelmann
Apr 23, 2003·Anesthesia and Analgesia·Joachim KlasenGunter Hempelmann
Oct 28, 2003·Annals of Surgery·Birgitte BrandstrupUNKNOWN Danish Study Group on Perioperative Fluid Therapy
Dec 9, 2003·Journal of Applied Physiology·Nina S Stachenfeld, Hugh S Taylor
Apr 7, 2005·Clinical Therapeutics·Rex N PonnuduraiAndrew N de la Torre
Jan 26, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Bernadette T Veering
Apr 14, 2006·Der Anaesthesist·T Koch, V Wenzel
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Fawzi A BabikerPieter A Doevendans
May 12, 2006·Der Anaesthesist·L AnisetM Schley
Mar 23, 2007·The Thoracic and Cardiovascular Surgeon·M CarlUNKNOWN German Society of Anaesthesiology and Intensive Care Medicine
May 19, 2009·Anesthesia and Analgesia·Periklis PanousisRainer J Litz
Oct 20, 2010·Resuscitation·Charles D DeakinGavin D Perkins
Citations
Dec 23, 2016·Der Anaesthesist·N KieferS U Weber
Feb 9, 2018·Current Medical Research and Opinion·Leopold EberhartPeter Kranke
Aug 17, 2017·Nature·Cody J WenthurKim D Janda
Dec 14, 2018·Journal of Anesthesia·Lutz KaufnerC von Heymann
Mar 9, 2017·Frontiers in Pharmacology·Berthold BeinLeopold H J Eberhart
Jun 8, 2017·Frontiers in Pharmacology·Benjamin KlothSebastian N Stehr
Aug 23, 2018·Der Anaesthesist·M WeitzelA Weyland
Nov 11, 2020·Der Anaesthesist·L EberhartUNKNOWN HYPOTENS study group
Jun 30, 2021·Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·Marius Keller, Harry Magunia