Cafedrine/theodrenaline in anaesthesia: influencing factors in restoring arterial blood pressure

Der Anaesthesist
A R HellerM P Müller

Abstract

Hypotensive states that require fast stabilisation of blood pressure can occur during anaesthesia. In 1963, the 20:1 mixture of cafedrine/theodrenaline (Akrinor) was introduced in Germany for use in anaesthesia and emergency medicine in the first-line management of hypotensive states. Though on the market for many years, few pharmacodynamic data are available on this combination net beta-mimetic agent. This study aimed to examine the drug combination in real-life clinical practice and recorded time to 10 % mean arterial blood pressure (MAP) increase and heart rate. Furthermore, potential factors that influence drug effectiveness under anaesthesia were assessed. Data were collected within a standardised anaesthesia protocol. A total of 353 consecutive patients (female/male = 149/204) who received cafedrine/theodrenaline after a drop in MAP ≥ 5% were included in the study. The time to 10 % increase in MAP, dosage of cafedrine/theodrenaline, volume loading, blood pressure and heart rate were monitored over time. Patients were a mean (standard deviation) of 64.4 ± 15.1 years old with a baseline MAP of 82 ± 14 mmHg, which dropped to a mean of 63 ± 10 mmHg during anaesthesia without gender differences. Cafedrine/theodrenaline (1.27 ±...Continue Reading

References

May 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P Morgan
Dec 9, 2003·Journal of Applied Physiology·Nina S Stachenfeld, Hugh S Taylor
Jan 26, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Bernadette T Veering
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Fawzi A BabikerPieter A Doevendans
May 12, 2006·Der Anaesthesist·L AnisetM Schley

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Citations

Jun 30, 2021·Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·Marius Keller, Harry Magunia

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