Caffeic acid as antioxidant in fish muscle: mechanism of synergism with endogenous ascorbic acid and alpha-tocopherol

Journal of Agricultural and Food Chemistry
Jacobo IglesiasIsabel Medina

Abstract

In an emulsion of corn oil in water with the addition of caffeic acid (Caf-OH) and alpha-tocopherol (alpha-TOH), Caf-OH was found to be very active in delaying lipid oxidation without affecting significantly the kinetics for alpha-TOH degradation. In contrast, Caf-OH addition to fish muscle retarded both the degradation of endogenous alpha-TOH and the propagation of lipid oxidation, measured by peroxide value (PV) and thiobarbituric acid reactive substances (TBARS), with increasing effect with increasing Caf-OH addition (55.5-555.1 micromol/kg). Electron spin resonance (ESR) spectroscopy confirmed a higher capacity of Caf-OH to regenerate alpha-TOH via reduction of the alpha-tocopheroxyl radical compared to other cinnamic acid derivatives (o-coumaric, ferulic, and chlorogenic acids). Degradation of endogenous ascorbate (AscH(-)) was accelerated at higher concentration of Caf-OH in fish tissue, suggesting a role of AscH(-) in the regeneration of Caf-OH. These results indicate that the antioxidant mechanism of Caf-OH implies the protection of endogenous alpha-TOH localized in tissue membranes where lipid oxidation is initiated and, at the same time, Caf-OH regeneration by the endogenous AscH(-). These combined effects result in a...Continue Reading

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Apr 23, 2008·Journal of Agricultural and Food Chemistry·Manuel PazosIsabel Medina

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Citations

May 13, 2011·Journal of Agricultural and Food Chemistry·Nick Emil GislasonAndrew Leo Waterhouse
Apr 14, 2011·Journal of Agricultural and Food Chemistry·Jacobo Iglesias NeiraIsabel Medina
May 4, 2011·Journal of Agricultural and Food Chemistry·Rodrigo MaestreIsabel Medina
Jan 1, 2014·Antioxidants·Monika SkowyraMaria Pilar Almajano
Aug 26, 2014·Food Chemistry·Mercedes AlemánAnn-Dorit Moltke Sørensen
Nov 26, 2016·International Journal of Molecular Sciences·Guadalupe Miroslava Suárez-JiménezWilfrido Torres-Arreola
Aug 31, 2011·Critical Reviews in Clinical Laboratory Sciences·Ivan Spasojević
Mar 5, 2016·Luminescence : the Journal of Biological and Chemical Luminescence·Abebe BelayYoon-Hwae Hwang
Jun 17, 2010·Journal of Agricultural and Food Chemistry·Jacobo IglesiasIsabel Medina
Jul 1, 2021·Comprehensive Reviews in Food Science and Food Safety·Shahzad FarooqJochen Weiss

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