Caffeic Acid-coated Nanolayer on Mineral Trioxide Aggregate Potentiate the Host Immune Responses, Angiogenesis, and Odontogenesis

Journal of Endodontics
Ming-Gene TuMing-You Shie

Abstract

The aim of this study was to investigate whether mineral trioxide aggregate (MTA) can be modified with caffeic acid (CA) to form caffeic acid/ mineral trioxide aggregate (CAMTA) cement and to evaluate for its physicochemical and biological properties, as well as its capability in immune suppression and angiogenesis. MTA was immersed in tris-buffer with CA to allow coating onto MTA powders. XRD and tensile stress-strain tests were conducted to assess for physical characteristics of CAMTA and to evaluate for successful modification of MTA. Then, the CAMTA cement was immersed in SBF to evaluate for its hydroxyapatite formation capabilities and Si release profiles. In addition, RAW 264.7 cells and human dental pulp stem cells (hDPSCs) were used to evaluate for its immune-suppressive capabilities and cell responses respectively. hDPSCs were also used to assess for CAMTA's angiogenic capabilities. The XRD results showed that CA can be successfully coated onto MTA without disrupting or losing of MTA's original structural properties, thus allowing us to retain initial advantages of MTA. CAMTA was shown to have higher mechanical properties as compared to MTA and had rougher pitted surfaces which were hypothesized to lead to enhanced adh...Continue Reading

References

Oct 31, 2002·International Endodontic Journal·H-X LuH-Y Guo
Aug 29, 2006·Journal of Endodontics·Ebtehal Al-RabeahDon MacFarland
Mar 1, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·B W Darvell, R C T Wu
Jul 25, 2012·International Endodontic Journal·K IoannidisV Karagiannis
Sep 2, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Chao-Hsin LiuMing-You Shie
Nov 7, 2015·Journal of Materials Science. Materials in Medicine·Ming-Gene TuMing-You Shie
Mar 2, 2016·Journal of Endodontics·Mariana O DaltoéLéa Assed Bezerra Silva
Dec 13, 2016·Journal of Endodontics·Ching-Yuang HuangMing-You Shie
Feb 12, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Ming-You ShieYi-Wen Chen
Feb 25, 2017·Dental Materials : Official Publication of the Academy of Dental Materials·Xin LiBart Van Meerbeek
Jul 25, 2017·Journal of Endodontics·Bruno Martini GuimarãesMarco Antonio Hungaro Duarte
Jun 2, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Huiyong XuXiaozhong Qiu
Jul 24, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Yi-Wen ChenMing-You Shie
Nov 15, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Farnaz GhorbaniMorteza Daliri Joupari
Feb 21, 2019·International Journal of Oral Science·Alexandra StähliReinhard Gruber
Mar 1, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Cambre N KellyDavid L Safranski
Sep 17, 2019·Journal of Endodontics·Yuan ZhaoJill A Helms
May 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mengchi XuChengtie Wu
Oct 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huiying ZhuChengtie Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Journal of the American Academy of Child and Adolescent Psychiatry
Tobias BanaschewskiADHD European Guidelines Group
Journal of the American Academy of Child and Adolescent Psychiatry
Steven R Pliszka
© 2021 Meta ULC. All rights reserved