Caffeic acid disturbs monocyte adhesion onto cultured endothelial cells stimulated by adipokine resistin

Journal of Agricultural and Food Chemistry
Eun-Sook LeeYoung-Hee Kang

Abstract

Adipokines have been implicated in the pathogenesis of atherosclerosis via pro-inflammatory mechanisms contributing to insulin resistance. The adipokine resistin causes endothelium dysfunction, which plays an important role in sustaining atherogenesis. This study investigated whether resistin induced expression of cell adhesion molecules and integrins in endothelial cells and THP-1 monocytes and whether such induction was attenuated by 1-20 μM caffeic acid. Resistin enhanced endothelial expression of vascular cell adhesion molecule 1 (VCAM-1), intercellular cell adhesion molecule 1 (ICAM-1), and E-selectin and monocyte expression of β1, β2, and α4 integrins. The enhancement of these proteins was diminished by caffeic acid with reduced THP-1 cell adhesion on activated endothelium. Caffeic acid at ≤20 μM demoted resistin-stimulated interleukin 8 (IL-8) production responsible for ICAM-1 and β2 integrin induction. The endothelial up-regulation of IL-8 secretion by resistin entailed toll-like receptor 4 (TLR4) activation, but caffeic acid diminished IL-8 production and TLR4 induction. Furthermore, caffeic acid encumbered resistin-activated nuclear factor κB (NF-κB) signaling. These results demonstrate that caffeic acid blocked monoc...Continue Reading

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Citations

May 7, 2013·Archives of Pharmacal Research·Sang Joon LeeHyun Chul Lee
Jul 26, 2012·Journal of Agricultural and Food Chemistry·Natalia KitsatiDimitrios Galaris
Aug 26, 2014·Pharmacological Reports : PR·Grzegorz SłomianPrzemysław Nowak
Oct 31, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Abdel-Rahman N ZekriTamer Mahmoud Elbaz
Apr 13, 2017·Postȩpy higieny i medycyny doświadczalnej·Grzegorz SłomianPrzemysław Nowak
Jul 3, 2021·International Journal of Molecular Sciences·Shiyao ZhangSiyu Chen

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