Caffeic acid phenethyl ester is protective in experimental ulcerative colitis via reduction in levels of pro-inflammatory mediators and enhancement of epithelial barrier function

Inflammopharmacology
Mohammed N KhanMurtaza M Tambuwala

Abstract

Inhibition of the nuclear factor kappa beta (NF-κβ) pathway has been proposed as a therapeutic target due to its key role in the expression of pro-inflammatory genes, including pro-inflammatory cytokines, chemokines, and adhesion molecules. Caffeic acid phenethyl ester (CAPE) is a naturally occurring anti-inflammatory agent, found in propolis, and has been reported as a specific inhibitor of NF-κβ. However, the impact of CAPE on levels of myeloperoxidases (MPO) and pro-inflammatory cytokines during inflammation is not clear. The aims of this study were to investigate the protective efficacy of CAPE in the mouse model of colitis and determine its effect on MPO activity, pro-inflammatory cytokines levels, and intestinal permeability. Dextran sulphate sodium was administered in drinking water to induce colitis in C57/BL6 mice before treatment with intraperitoneal administration of CAPE (30 mg kg-1 day-1). Disease activity index (DAI) score, colon length and tissue histology levels of MPO, pro-inflammatory cytokines, and intestinal permeability were observed. CAPE-treated mice had lower DAI and tissue inflammation scores, with improved epithelial barrier protection and significant reduction in the level of MPO and pro-inflammatory ...Continue Reading

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Citations

Jan 8, 2020·Current Drug Delivery·Garima ShrivastavaMurtaza M Tambuwala
Jun 4, 2020·International Journal of Molecular Sciences·Tripti KhareSharad Khare
Aug 11, 2020·Journal of Food Biochemistry·Gengen ShiLianggong Zhao
Feb 13, 2020·Molecular Medicine·Jihui JuPing Zhang
Aug 5, 2019·Inflammation·Hamid A BakshiMurtaza M Tambuwala
Jan 14, 2020·BioMed Research International·Hitomi KuramotoTakashi Matsuo
Jan 26, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Lili LvLongfei Yang
Jul 30, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Esra Küpeli AkkolHaroon Khan
Nov 27, 2021·Phytotherapy Research : PTR·Fahimeh Zamani-GarmsiriReza Meshkani

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