Caffeic acid phenethyl ester reduces the activation of the nuclear factor κB pathway by high-fat diet-induced obesity in mice

Metabolism: Clinical and Experimental
Rosângela Maria Neves BezerraSeverino Matias de Alencar

Abstract

The aim of this study was to investigate the effect of CAPE on the insulin signaling and inflammatory pathway in the liver of mice with high fat diet induced obesity. Swiss mice were fed with standard chow or high-fat diet for 12-week. After the eighth week, animals in the HFD group with serum glucose levels higher than 200 mg/dL were divided into two groups, HFD and HFD receiving 30 mg/kg of CAPE for 4 weeks. After 12 weeks, the blood samples could be collected and liver tissue extracted for hormonal and biochemical measurements, and insulin signaling and inflammatory pathway analyzes. The high-fat diet group exhibited more weight gain, glucose intolerance, and hepatic steatosis compared with standard diet group. The CAPE treatment showed improvement in glucose sensitivity characterized by an area under glucose curve similar to the control group in an oral glucose tolerance test Furthermore, CAPE treatment promoted amelioration in hepatic steatosis compared with the high-fat diet group. The increase in glucose sensitivity was associated with the improvement in insulin-stimulated phosphorylation of the insulin receptor substrate-2, followed by an increase in Akt phosphorylation. In addition, it was observed that CAPE reduced th...Continue Reading

References

Aug 22, 2001·Trends in Cell Biology·V Baud, M Karin
May 25, 2002·British Journal of Pharmacology·Pasquale MaffiaArmando Ialenti
Nov 26, 2002·Nature·Jiro HirosumiGökhan S Hotamisligil
Jul 25, 2003·Brain Research. Molecular Brain Research·Pascale MontpiedJoël Bockaert
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Claudia E Carrasco-LegleuSaúl Villa-Treviño
Dec 7, 2007·FEBS Letters·Carl de Luca, Jerrold M Olefsky
Jul 18, 2009·International Journal of Cancer. Journal International Du Cancer·Takeshi ToyodaMasae Tatematsu
Sep 1, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sefa CelikMehmet Tuzcu
May 25, 2010·Metabolism: Clinical and Experimental·Christian L RothThomas Reinehr
Oct 26, 2010·European Heart Journal·Emanuela FalaschettiJohn E Deanfield

❮ Previous
Next ❯

Citations

Jul 3, 2015·Experimental and Therapeutic Medicine·Ferah ArmutcuFatime Filiz Turan
Jun 25, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Ricardo Silva-CarvalhoCristina Almeida-Aguiar
May 11, 2016·Chemico-biological Interactions·Cuiyun LiXiaopeng Hu
Nov 25, 2014·Journal of Agricultural and Food Chemistry·Shota MiyataKen Kobayashi
Dec 17, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jae Ho ChoiHye Gwang Jeong
Feb 4, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B M BoccoM O Ribeiro
Feb 8, 2019·Current Pharmaceutical Biotechnology·Rawan ZeitounYolla El-Makhour
Apr 9, 2015·World Journal of Gastroenterology : WJG·Mei LiShuang-Suo Dang
Mar 11, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Lingjie KongHongcheng Zhang
Mar 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Iqra LiaquatSalman Khan
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Batoryna OlgierdMorawiec Emilia
May 1, 2021·Applied Microbiology and Biotechnology·Daniel A Grajales-HernándezJuan Carlos Mateos-Díaz
Apr 20, 2021·Fundamental & Clinical Pharmacology·Nadeem IrshadShupeng Li
Aug 2, 2019·Journal of Agricultural and Food Chemistry·Bruno Dias NaniPedro Luiz Rosalen
Sep 28, 2021·Frontiers in Cell and Developmental Biology·Xiao ShengHaiyang Chen
Apr 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vahid Reza AskariHassan Rakhshandeh
Nov 27, 2021·Phytotherapy Research : PTR·Fahimeh Zamani-GarmsiriReza Meshkani

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.