PMID: 1190514Jan 1, 1975Paper

Caffeine- and kallikrein-induced stimulation of human sperm motility: a comparative study

W B Schill


Stimulation of human sperm motility by caffeine and kallikrein was compared in the same semen material. Caffeine, a cyclic nucleotide phosphodiesterase inhibitor, induced an immediate stimulation of sperm motility the intensity being relatively constant during the first two hours of incubation. Kallikrein, a kinin-releasing proteinase, induced a similar enhancement of total sperm motility, but showed a delayed type of reaction with maximum stimulation at 2 hours of incubation. In contrast to the effect of caffeine lasting some hours, enhancement of sperm motility induced by kallikrein was observed 24 hours. Simultaneous addition of serum (kininogen source) and kallikrein to semen samples led to a sitmulation of total sperm motility with higher mean values than those obtained by caffeine of kallikrein alone. However, the ratio of spermatozoa with very good forward progression was highest during caffeine stimulation. Simultaneous addition of caffeine and kallikrein led to a further improvement of sperm motility which was significantly above that produced by caffeine or kallikrein alone. This observation and the finding of a different response of the spermatozoa of two ejaculates towards caffeine of kallikrein indicate that caffei...Continue Reading


Aug 31, 1973·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J S Tash, T Mann
Jul 27, 1970·Biochemical and Biophysical Research Communications·E R Casillas, D D Hoskins
May 18, 1971·Biochimica Et Biophysica Acta·D D HoskinsE R Casillas
Nov 1, 1971·Archives of Biochemistry and Biophysics·E R Casillas, D D Hoskins
Dec 1, 1972·Biology of Reproduction·A SosaA Rosado
Sep 1, 1973·Fertility and Sterility·A Haesungcharern, M Chulavatnatol
Oct 1, 1973·Fertility and Sterility·C SchoenfeldL Dubin

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Jul 20, 1979·Archives of Gynecology·W B Schill
Mar 1, 1980·Archives of Andrology·S J MultamäkiB M Djupsund
Jan 1, 1995·International Urology and Nephrology·S AydinB Alagöl
Jan 1, 1996·International Urology and Nephrology·S AydinG Dellaloğlu
Jan 1, 1988·Archives of Andrology·S Saito, Y Kumamoto
Jul 20, 2007·The Cochrane Database of Systematic Reviews·P VandekerckhoveE Hughes
Dec 1, 1995·European Journal of Biochemistry·F EspañaK Witzgall
Dec 19, 2007·Asian Journal of Andrology·F DimitriadisN Sofikitis
May 5, 2000·The Cochrane Database of Systematic Reviews·P VandekerckhoveE Hughes
Dec 25, 2013·International Journal of Biological Macromolecules·Sanjay KumarSavita Yadav

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