PMID: 6413433Oct 15, 1983Paper

Caffeine (1,3,7-trimethylxanthine), a temperature promoter of DMBA-induced rat mammary gland carcinogenesis

International Journal of Cancer. Journal International Du Cancer
C W WelschJ V DeHoog

Abstract

The administration of caffeine to the drinking water (250 mg/l and 500 mg/l) of female Sprague-Dawley rats after treatment with 7,12-dimethylbenzanthracene (DMBA) (5 mg i.g.) resulted in an increase in mammary carcinoma incidence. The confidence levels of statistical significance for the groups of rats receiving the 250-mg and 500-mg doses of caffeine were greater than 0.70 and greater than 0.99, respectively. This increase in mammary carcinoma incidence was observed when caffeine treatment was initiated commencing 3 days after DMBA treatment and continued for 21 weeks. This effect was also observed when caffeine treatment was initiated commencing 20 weeks after DMBA treatment and continued for 6 weeks in rats relatively refractory to carcinogen treatment (mammary tumor-free at onset of treatment) and in rats relatively sensitive to the carcinogen (mammary tumor bearing at onset of caffeine treatment). Caffeine treatment of rats prior to and during carcinogen treatment did not significantly affect mammary carcinoma incidence. Thus caffeine consumption has been shown to significantly enhance the promoting phase but is without effect on the initiating phase of this carcinogenic process.

References

Mar 1, 1979·Cancer Treatment Reviews·M J Tisdale
Jul 1, 1973·Canadian Journal of Physiology and Pharmacology·W R Thorpe
Nov 1, 1973·British Journal of Cancer·D H Shennan
Aug 1, 1968·Metabolism: Clinical and Experimental·S BelletE M Finck
Apr 1, 1969·Metabolism: Clinical and Experimental·S BelletA Kershbaum
Jun 1, 1982·American Journal of Public Health·J MarshallM Swanson
Mar 12, 1981·The New England Journal of Medicine·B MacMahonG Nardi
Apr 25, 1964·The Tohoku Journal of Experimental Medicine·E TAKAHASHI
Aug 1, 1964·Cancer·H H DAVISJ B DAVIS

❮ Previous
Next ❯

Citations

Oct 23, 2009·Breast Cancer Research and Treatment·Nirmala Bhoo PathyCuno S P M Uiterwaal
Dec 1, 1988·Mutation Research·D A BoothmanA B Pardee
Jan 11, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S M TarkaC A Shively
May 11, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S HosakaK Kiyosawa
Jan 1, 1987·Journal of Toxicology and Environmental Health·D K Liu, G F Owens
Sep 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yao-Ping LuAllan H Conney
Jan 27, 2004·Journal of Cellular Biochemistry·Allan H Conney
Oct 15, 1987·International Journal of Cancer. Journal International Du Cancer·C SchairerR N Hoover
Nov 1, 1988·Journal of Pharmaceutical Sciences·N LanderC C Gairola
Aug 22, 2021·International Journal of Cancer. Journal International Du Cancer·Kan Hong ZhengLina Mu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.