Caffeine: a potential complexing agent for solubility and dissolution enhancement of celecoxib

Pharmaceutical Biology
Faiyaz Shakeel, Mohammed S Faisal

Abstract

Complexation of caffeine with the drug celecoxib was used to enhance its solubility as well as in vitro dissolution in the present investigation. Caffeine was extracted from tea leaves using the sublimation method. A molecular complex (1:1) of caffeine-celecoxib was prepared using the solubility method. The solubility of celecoxib in distilled water and the caffeine complex was determined using a HPLC method at a wavelength of 250 nm. Dissolution studies of pure celecoxib, a marketed capsule (Celebrex), and the complex were performed using USP dissolution apparatus I for pure celecoxib and the complex and apparatus II for the capsule in distilled water. The highest solubility (48.32 mg/mL) as well as percent dissolution (90.54%) of celecoxib was obtained with the caffeine-celecoxib complex. The results for solubility and dissolution were highly significant as compared to pure celecoxib and the marketed capsule (p < 0.01). These results suggest that caffeine is a promising complexing agent for solubility as well as dissolution enhancement of the poorly soluble drug celecoxib.

References

Feb 4, 2006·Biophysical Chemistry·M P EvstigneevD B Davies
Oct 25, 2006·European Biophysics Journal : EBJ·M P EvstigneevD B Davies
Aug 12, 2008·Current Pharmaceutical Biotechnology·Michal Sabisz, Andrzej Skladanowski
Nov 6, 2008·Journal of Drug Targeting·Faiyaz ShakeelSheikh Shafiq

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Citations

Jun 19, 2012·Expert Opinion on Drug Delivery·Faiyaz ShakeelIbrahim A Alsarra
Mar 5, 2011·Journal of Pharmaceutical Sciences·H-G LeeD R Flanagan
Jul 16, 2020·Advanced Pharmaceutical Bulletin·Avinash Ramrao Tekade, Jyoti Narayan Yadav

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